Squamous cell lung carcinoma

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This study tests whether text-based support can help rural cancer survivors who smoke to quit. Participants will either receive text messages that gradually reduce cigarette use or a self-help manual. The goal is to see which approach works better for long-term smoking cessation.

This study tests a new drug called AZD5335, alone or with other cancer medicines, in people with advanced solid tumors like ovarian, lung, and endometrial cancers. The goal is to see if the drug is safe, tolerable, and shows signs of shrinking tumors. About 506 participants will …

This study compares a new smartphone app called IndigeQuit to an existing app (NCI QuitGuide) to help American Indian and Alaska Native adults quit smoking. About 776 participants who smoke daily and want to quit within 30 days will be randomly assigned to use one of the apps. Th…

This trial compares oral nicotine pouches (like ZYN) with standard nicotine replacement therapy (patches and lozenges) to help smokers in rural Appalachia reduce or stop cigarette use. The goal is to lower the high rates of lung and oral cancers linked to smoking in this region. …

This study tests whether matching smoking cessation treatments—like nicotine patches, counseling, or medications—to a person's unique traits can help them quit. About 2,010 smokers who want to quit will receive personalized care. The goal is to find better ways to help people sto…

This study looks at whether flavored e-cigarettes (tobacco vs. non-tobacco) or nicotine patches and lozenges work better to help people stop smoking regular cigarettes. Researchers will track how many participants quit smoking completely over 7 days. The goal is to find out which…

This phase 2 trial is testing a drug called ZEN003694 in 13 people with advanced squamous cell lung cancer that has a specific gene change (NSD3 amplification). The drug works by blocking certain proteins that may help the cancer grow. Researchers want to see if it can shrink tum…

This early-stage trial tests a new treatment called C-CAR031 for people with advanced squamous cell lung cancer that has stopped responding to standard therapies. The treatment uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cells. The m…

This early-stage trial tests a new drug called JMT106 in 200 people with advanced solid tumors, including lung and liver cancers, who have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug shows any sign of shrinkin…

This phase 2 trial tests whether adding low-dose radiation to standard immunotherapy (sintilimab) and chemotherapy can shrink tumors better than immunotherapy and chemo alone in people with advanced squamous cell lung cancer. About 114 participants will be randomly assigned to on…

This study tests whether a broccoli seed and sprout extract can help heavy smokers break down and remove cancer-causing chemicals from tobacco. About 135 current smokers will take either the extract or a placebo daily for several weeks. Researchers will measure changes in urine l…

This study looks at how much nicotine, cannabis, and harmful chemicals end up in the blood and urine of young adults (ages 18-25) who use e-cigarettes, cannabis, or both. Researchers will compare these levels across different user groups and also track their habits through questi…

This study interviews 40 young adults aged 18-30 who use both tobacco (cigarettes or vaping) and cannabis at least weekly. Researchers want to learn how and why people start, increase, and keep using both substances together. The goal is to better understand these behaviors, not …

This study aims to collect health information from 12,000 adults with lung or other chest cancers. Researchers want to understand why some people respond better to treatment than others, even when their cancer stage is the same. By gathering data from routine care, they hope to i…

This large study in Ohio is looking at whether advanced genomic testing and immunotherapy decision support can help people with stage IV non-small cell lung cancer live longer and have a better quality of life. Researchers will compare standard care with a more personalized appro…

This study tests a program called CONNECTing to LungCare that helps smokers have better conversations with their doctors about quitting smoking and getting screened for lung cancer. The program includes educational materials and a personalized summary to guide discussions. Resear…

This study looks at whether daily menthol smokers can tell if a cigarette has menthol flavor or not. Researchers want to see if cigarettes sold in California (where menthol is banned) still taste minty to smokers from New York. The goal is to understand how well people can detect…

This study looks at how the cooling sensation in oral nicotine pouches (like ZYN) influences smokers' appeal and cravings. Thirty adult smokers will try different pouches and rate their experience. The goal is to understand if these products could help people switch from cigarett…