Radiation boosts immunotherapy in lung cancer trial

NCT ID NCT06121505

Recruiting now Disease control Sponsor: Sichuan University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tests whether adding low-dose radiation to standard immunotherapy (sintilimab) and chemotherapy can shrink tumors better than immunotherapy and chemo alone in people with advanced squamous cell lung cancer. About 114 participants will be randomly assigned to one of two groups. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sintilimab (PD-1 inhibitor) plus chemotherapy, with low-dose radiation therapy and stereotactic body radiation therapy
What this could lead to: If it works, this could offer a more effective first-line treatment for advanced squamous cell lung cancer by combining radiation with immunotherapy and chemo.
What could go wrong: This is a small, early-phase (Phase 2) trial with only 114 participants. Adding radiation may increase side effects, and the benefit over standard treatment is not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

squamous cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG SQUAMOUS CELL CARCINOMA

Contacts and locations

Locations

Affiliated Hospital of North Sichuan Medical College
RECRUITING

Nanchong, Sichuan, 637503, China
Guizhou Provincial People's Hospital
RECRUITING

Guiyang, Guizhou, 550002, China
Sichuan Cancer Hospital
RECRUITING

Chengdu, Sichuan, 610044, China
The Second Affiliated Hospital of Chongqing Medical University
RECRUITING

Chongqing, Chongqing Municipality, 400010, China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
RECRUITING

Wuhan, Hunan, 430022, China
West China Hospital of Sichuan University
RECRUITING

Chengdu, Sichuan, 610044, China

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