Squamous cell lung carcinoma

This study looked at whether adding metformin (a common diabetes medicine) to standard chemotherapy and radiation helps people with stage III non-small cell lung cancer live longer without their cancer getting worse. About 170 adults with advanced lung cancer took part. The goal …

This early-phase study tests a new oral drug called TT125-802 in 50 adults with advanced solid tumors (like lung cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see if it can shrink tumors. It is a fi…

This phase 2 trial tested whether adding an experimental drug called AZD1775 to standard chemotherapy (carboplatin and paclitaxel) could help people with advanced squamous cell lung cancer. The study enrolled 42 participants and measured how long they lived without their cancer g…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This study tested two drugs—auranofin (originally for arthritis) and sirolimus (an immune suppressant)—in 29 people with advanced or recurrent lung cancer who had no standard options left. The goal was to find the safest dose and see if the combination could slow cancer growth. T…

This study tests a technique called episodic future thinking (EFT) to help smokers reduce cigarette use. Participants imagine positive events they look forward to in the next year, like a vacation or family gathering, and receive smartphone prompts. The goal is to see if focusing…

This study tests whether canakinumab, a drug that blocks inflammation, can lower certain proteins linked to cancer growth in former smokers at high risk. About 41 participants will provide cheek, nose, and blood samples before and after treatment. The goal is to see if the drug c…

This study investigates whether a simple blood test (liquid biopsy) can track how advanced non-small cell lung cancer changes during immunotherapy or targeted therapy. Researchers will analyze tumor DNA circulating in the blood to see if it can predict treatment response and dete…

This study looked at whether synthetic cooling agents, which replace banned menthol in cigarettes, change how appealing or addictive cigarettes are. Researchers had 34 young adult smokers try these new cigarettes and measured their smoking behavior and preferences. The goal was t…

This study looked at how men and women react differently when they switch from regular cigarettes to a standard research e-cigarette. About 169 adult smokers took part. The goal was to understand if gender affects how much people use e-cigarettes and how dependent they become on …

This study from M.D. Anderson Cancer Center tested what happens when daily and occasional smokers use very low nicotine cigarettes along with e-cigarettes that have different nicotine levels. Researchers measured how many cigarettes people smoked, their nicotine levels, and withd…