Could a diabetes drug boost lung cancer treatment?

NCT ID NCT02186847

Completed Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 2 times

Summary

This study looked at whether adding metformin (a common diabetes medicine) to standard chemotherapy and radiation helps people with stage III non-small cell lung cancer live longer without their cancer getting worse. About 170 adults with advanced lung cancer took part. The goal was to see if metformin could improve treatment results, but it is not a cure—patients still need ongoing monitoring and care.

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma of Lung adenosquamous lung carcinoma lung adenocarcinoma lung adenocarcinoma in situ lung large cell carcinoma minimally invasive lung adenocarcinoma non-small cell lung carcinoma squamous cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADENOSQUAMOUS LUNG CARCINOMA BRONCHIOLOALVEOLAR CARCINOMA LARGE CELL LUNG CARCINOMA LUNG ADENOCARCINOMA NON-SMALL CELL LUNG CARCINOMA RECURRENT NON-SMALL CELL LUNG CARCINOMA SQUAMOUS CELL LUNG CARCINOMA STAGE IIIA NON-SMALL CELL LUNG CANCER STAGE IIIB NON-SMALL CELL LUNG CANCER

Contacts and locations

Locations

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407, United States
Adena Regional Medical Center

Chillicothe, Ohio, 45601, United States
Allan Blair Cancer Centre

Regina, Saskatchewan, S4T 7T1, Canada
AnMed Health Cancer Center

Anderson, South Carolina, 29621, United States
Ascension Columbia Saint Mary's Hospital - Milwaukee

Milwaukee, Wisconsin, 53211, United States
Ascension Columbia Saint Mary's Hospital Ozaukee

Mequon, Wisconsin, 53097, United States
Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214, United States
Aspirus Cancer Care - Stevens Point

Stevens Point, Wisconsin, 54481, United States
Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494, United States
Augusta Health Center for Cancer and Blood Disorders

Fishersville, Virginia, 22939, United States
Aultman Health Foundation

Canton, Ohio, 44710, United States
Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311, United States
Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024, United States
Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142, United States
Aurora Medical Center in Summit

Summit, Wisconsin, 53066, United States
Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Aurora West Allis Medical Center

West Allis, Wisconsin, 53227, United States
Banner North Colorado Medical Center

Greeley, Colorado, 80631, United States
Banner North Colorado Medical Center - Loveland Campus

Loveland, Colorado, 80539, United States
Banner University Medical Center - Tucson

Tucson, Arizona, 85719, United States
Baptist Health Hardin

Elizabethtown, Kentucky, 42701, United States
Baptist Health Lexington

Lexington, Kentucky, 40503, United States
Bay Area Medical Center

Marinette, Wisconsin, 54143, United States
Billings Clinic Cancer Center

Billings, Montana, 59101, United States
Boston Medical Center

Boston, Massachusetts, 02118, United States
CHI Health Good Samaritan

Kearney, Nebraska, 68847, United States
Cancer Center of Putnam

Palatka, Florida, 32177, United States
Cancer Center of Western Wisconsin

New Richmond, Wisconsin, 54017, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
CaroMont Regional Medical Center

Gastonia, North Carolina, 28054, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Central Vermont Medical Center/National Life Cancer Treatment

Berlin Corners, Vermont, 05602, United States
Chaim Sheba Medical Center

Tel Litwinsky, 52621, Israel
Christiana Care Health System-Christiana Hospital

Newark, Delaware, 19718, United States
Cleveland Clinic Cancer Center Independence

Independence, Ohio, 44131, United States
Cleveland Clinic Cancer Center Strongsville

Strongsville, Ohio, 44136, United States
Cleveland Clinic Cancer Center/Fairview Hospital

Cleveland, Ohio, 44111, United States
Cleveland Clinic Foundation

Cleveland, Ohio, 44195, United States
Cleveland Clinic Mercy Hospital

Canton, Ohio, 44708, United States
Cleveland Clinic Wooster Family Health and Surgery Center

Wooster, Ohio, 44691, United States
Community Medical Center

Missoula, Montana, 59804, United States
Community Medical Center

Toms River, New Jersey, 08755, United States
Corewell Health Beaumont Troy Hospital

Troy, Michigan, 48085, United States
Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503, United States
Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
CoxHealth South Hospital

Springfield, Missouri, 65807, United States
Dartmouth Cancer Center - North

Saint Johnsbury, Vermont, 05819, United States
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center

Lebanon, New Hampshire, 03756, United States
Decatur Memorial Hospital

Decatur, Illinois, 62526, United States
Eden Hospital Medical Center

Castro Valley, California, 94546, United States
Emory Decatur Hospital

Decatur, Georgia, 30033, United States
Fairview Southdale Hospital

Edina, Minnesota, 55435, United States
FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374, United States
Franciscan Health Indianapolis

Indianapolis, Indiana, 46237, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Gaston Hematology and Oncology Associates

Gastonia, North Carolina, 28054, United States
Gaston Hematology and Oncology Associates-Belmont

Belmont, North Carolina, 28012, United States
Geauga Hospital

Chardon, Ohio, 44024, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701, United States
Gibbs Cancer Center-Pelham

Greer, South Carolina, 29651, United States
Good Samaritan Hospital - Dayton

Dayton, Ohio, 45406, United States
Hennepin County Medical Center

Minneapolis, Minnesota, 55415, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Hillcrest Hospital Cancer Center

Mayfield Heights, Ohio, 44124, United States
Houston Methodist Hospital

Houston, Texas, 77030, United States
IU Health Bloomington

Bloomington, Indiana, 47408, United States
Intermountain Health Lutheran Hospital

Wheat Ridge, Colorado, 80401, United States
Intermountain Medical Center

Murray, Utah, 84107, United States
Jefferson Abington Hospital

Abington, Pennsylvania, 19001, United States
Jewish General Hospital

Montreal, Quebec, H3T 1E2, Canada
John B Amos Cancer Center

Columbus, Georgia, 31904, United States
John H Stroger Jr Hospital of Cook County

Chicago, Illinois, 60612, United States
Kaiser Permanente Cancer Treatment Center

South San Francisco, California, 94080, United States
Kaiser Permanente Oakland-Broadway

Oakland, California, 94611, United States
Kaiser Permanente-Rancho Cordova Cancer Center

Rancho Cordova, California, 95670, United States
Kettering Medical Center

Kettering, Ohio, 45429, United States
Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854, United States
LSU Health Baton Rouge-North Clinic

Baton Rouge, Louisiana, 70805, United States
Lankenau Medical Center

Wynnewood, Pennsylvania, 19096, United States
Lawrence Memorial Hospital

Lawrence, Kansas, 66044, United States
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405, United States
Lewis and Faye Manderson Cancer Center

Tuscaloosa, Alabama, 35401, United States
Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809, United States
Lowell General Hospital

Lowell, Massachusetts, 01854, United States
MD Anderson West Houston

Houston, Texas, 77079, United States
MD Anderson in Sugar Land

Sugar Land, Texas, 77478, United States
MD Anderson in The Woodlands

Conroe, Texas, 77384, United States
MaineHealth Maine Medical Center- Scarborough

Scarborough, Maine, 04074, United States
Marshfield Medical Center - Minocqua

Minocqua, Wisconsin, 54548, United States
Marshfield Medical Center - Weston

Weston, Wisconsin, 54476, United States
Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449, United States
Marshfield Medical Center-Rice Lake

Rice Lake, Wisconsin, 54868, United States
Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809, United States
Mary Bird Perkins Cancer Center - Covington

Covington, Louisiana, 70433, United States
Mary Bird Perkins Cancer Center - Houma

Houma, Louisiana, 70360, United States
McLaren Cancer Institute-Central Michigan

Mount Pleasant, Michigan, 48858, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren Cancer Institute-Owosso

Owosso, Michigan, 48867, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Memorial Health University Medical Center

Savannah, Georgia, 31404, United States
Memorial Medical Center

Modesto, California, 95355, United States
Mercy Cancer Center - Cape Girardeau

Cape Girardeau, Missouri, 63703, United States
Mercy Cancer Center-Elyria

Elyria, Ohio, 44035, United States
Mercy Hospital

Cedar Rapids, Iowa, 52403, United States
Mercy Hospital

Coon Rapids, Minnesota, 55433, United States
Mercy Hospital Saint Louis

St Louis, Missouri, 63141, United States
Methodist Medical Center of Illinois

Peoria, Illinois, 61636, United States
Missouri Baptist Medical Center

St Louis, Missouri, 63131, United States
Mount Carmel Health Center West

Columbus, Ohio, 43222, United States
Nebraska Cancer Specialists/Oncology Hematology West PC

Grand Island, Nebraska, 68803, United States
Nebraska Methodist Hospital

Omaha, Nebraska, 68114, United States
New Mexico Oncology Hematology Consultants

Albuquerque, New Mexico, 87109, United States
New York-Presbyterian/Brooklyn Methodist Hospital

Brooklyn, New York, 11215, United States
Newark Radiation Oncology

Newark, Ohio, 43055, United States
North Coast Cancer Care

Sandusky, Ohio, 44870, United States
North Kansas City Hospital

Kansas City, Missouri, 64116, United States
Northeast Radiation Oncology Center

Dunmore, Pennsylvania, 18512, United States
Northwest Community Hospital

Arlington Heights, Illinois, 60005, United States
OSF Saint Francis Medical Center

Peoria, Illinois, 61637, United States
OSF Saint Francis Radiation Oncology at Pekin

Pekin, Illinois, 61554, United States
OSF Saint Francis Radiation Oncology at Peoria Cancer Center

Peoria, Illinois, 61615, United States
Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States
Orlando Health Cancer Institute

Orlando, Florida, 32806, United States
Our Lady of the Lake Physician Group

Baton Rouge, Louisiana, 70808, United States
Parkview Hospital Randallia

Fort Wayne, Indiana, 46805, United States
PeaceHealth Saint John Medical Center

Longview, Washington, 98632, United States
PeaceHealth Southwest Medical Center

Vancouver, Washington, 98664, United States
Penrose-Saint Francis Healthcare

Colorado Springs, Colorado, 80907, United States
Phelps Health Delbert Day Cancer Institute

Rolla, Missouri, 65401, United States
Piedmont Hospital

Atlanta, Georgia, 30309, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316, United States
Queen's Medical Center

Honolulu, Hawaii, 96813, United States
Radiation Oncology Associates PC

Fort Wayne, Indiana, 46804, United States
Reading Hospital

West Reading, Pennsylvania, 19611, United States
Regions Hospital

Saint Paul, Minnesota, 55101, United States
Rice Memorial Hospital

Willmar, Minnesota, 56201, United States
Riverside Methodist Hospital

Columbus, Ohio, 43214, United States
Rohnert Park Cancer Center

Rohnert Park, California, 94928, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
SSM Health Good Samaritan

Mount Vernon, Illinois, 62864, United States
Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Saint Francis Medical Center

Cape Girardeau, Missouri, 63703, United States
Saint Joseph Medical Center Hematology and Oncology - Silverdale

Silverdale, Washington, 98383, United States
Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301, United States
Saint Luke's Hospital of Duluth

Duluth, Minnesota, 55805, United States
Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501, United States
Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601, United States
Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122, United States
Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134, United States
Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
South Sacramento Cancer Center

Sacramento, California, 95823, United States
Southern Ohio Medical Center

Portsmouth, Ohio, 45662, United States
Spartanburg Medical Center

Spartanburg, South Carolina, 29303, United States
Springfield Memorial Hospital

Springfield, Illinois, 62781, United States
Sutter Cancer Centers Radiation Oncology Services-Auburn

Auburn, California, 95603, United States
Sutter Cancer Centers Radiation Oncology Services-Cameron Park

Cameron Park, California, 95682, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville

Roseville, California, 95661, United States
Sutter Medical Center Sacramento

Sacramento, California, 95816, United States
Swedish Medical Center

Englewood, Colorado, 80113, United States
The Cancer Center of Hawaii-Liliha

Honolulu, Hawaii, 96817, United States
The Cancer Center of Hawaii-Pali Momi

‘Aiea, Hawaii, 96701, United States
The Mark H Zangmeister Center

Columbus, Ohio, 43219, United States
The Permanente Medical Group-Roseville Radiation Oncology

Roseville, California, 95678, United States
The University of Kansas Cancer Center-South

Kansas City, Missouri, 64131, United States
Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107, United States
TidalHealth Peninsula Regional

Salisbury, Maryland, 21801, United States
Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503, United States
Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444, United States
Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341, United States
UC San Diego Moores Cancer Center

La Jolla, California, 92093, United States
UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909, United States
UCHealth University of Colorado Hospital

Aurora, Colorado, 80045, United States
UCSF Medical Center-Mount Zion

San Francisco, California, 94115, United States
UH Seidman Cancer Center at Firelands Regional Medical Center

Sandusky, Ohio, 44870, United States
UH Seidman Cancer Center at Lake Health Mentor Campus

Mentor, Ohio, 44060, United States
UH Seidman Cancer Center at Southwest General Hospital

Middleburg Heights, Ohio, 44130, United States
UHHS-Chagrin Highlands Medical Center

Beachwood, Ohio, 44122, United States
UHHS-Westlake Medical Center

Westlake, Ohio, 44145, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UM Upper Chesapeake Medical Center

Bel Air, Maryland, 21014, United States
UPMC Hillman Cancer Center Erie

Erie, Pennsylvania, 16505, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
UT MD Anderson - League City

League City, Texas, 77573, United States
UT MD Anderson Cancer Center

Houston, Texas, 77030, United States
UTMB Cancer Center at Victory Lakes

League City, Texas, 77573, United States
United Hospital

Saint Paul, Minnesota, 55102, United States
University Hospitals Parma Medical Center

Parma, Ohio, 44129, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Nebraska Medical Center

Omaha, Nebraska, 68198, United States
University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Rochester

Rochester, New York, 14642, United States
University of Texas Medical Branch

Galveston, Texas, 77555-0565, United States
University of Vermont Medical Center

Burlington, Vermont, 05401, United States
Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241, United States
Virtua Memorial

Mount Holly, New Jersey, 08060, United States
Virtua Voorhees

Voorhees Township, New Jersey, 08043, United States
Wentworth-Douglass Hospital

Dover, New Hampshire, 03820, United States
Wesley Medical Center

Wichita, Kansas, 67214, United States
West Michigan Cancer Center

Kalamazoo, Michigan, 49007, United States
Wheeling Hospital/Schiffler Cancer Center

Wheeling, West Virginia, 26003, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

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