Soft tissue sarcoma
MONDO:0018078A malignant neoplasm arising from muscle tissue, adipose tissue, blood vessels, fibrous tissue, or other supportive tissues excluding the bones.
Also known as: malignant soft tissue tumor, malignant soft tissue tumour, connective tissue sarcoma, malignant mesenchymal tumor, malignant mesenchymal tumour, non-Rhabdo. soft tissue sarcoma, sarcoma of soft tissue, sarcoma of the soft tissue
3373 clinical trials for this condition and its sub-types, 297 tagged with Soft tissue sarcoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Soft tissue sarcoma
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Rhabdomyosarcoma 100 trials · 114 incl. sub-types
20 sub-types
- Alveolar rhabdomyosarcoma 9 trials
- Pleomorphic rhabdomyosarcoma 7 trials Sub-types →
- Embryonal rhabdomyosarcoma 4 trials Sub-types →
- Spindle cell rhabdomyosarcoma 3 trials Sub-types →
- Testis rhabdomyosarcoma 1 trial
- Breast rhabdomyosarcoma 0 trials
- Central nervous system rhabdomyosarcoma 0 trials
- Gallbladder rhabdomyosarcoma 0 trials
- Liver rhabdomyosarcoma 0 trials Sub-types →
- Mediastinum rhabdomyosarcoma 0 trials
- Oral rhabdomyosarcoma 0 trials
- Orbit rhabdomyosarcoma 0 trials Sub-types →
- Ovary rhabdomyosarcoma 0 trials
- Prostate rhabdomyosarcoma 0 trials Sub-types →
- Rectum rhabdomyosarcoma 0 trials Sub-types →
- Rhabdomyosarcoma of the cervix uteri 0 trials
- Rhabdomyosarcoma with mixed embryonal and alveolar features 0 trials
- Rhabdomyosarcoma, embryonal, 2 0 trials
- Uterine corpus rhabdomyosarcoma 0 trials
- Vaginal rhabdomyosarcoma 0 trials Sub-types →
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Liposarcoma 58 trials · 83 incl. sub-types
19 sub-types
- Dedifferentiated liposarcoma 37 trials
- Myxoid/round cell liposarcoma 13 trials · 18 incl. sub-types Sub-types →
- Pleomorphic liposarcoma 8 trials
- Well-differentiated liposarcoma 5 trials Sub-types →
- Adult liposarcoma 0 trials
- Breast liposarcoma 0 trials
- Cutaneous liposarcoma 0 trials
- Esophagus liposarcoma 0 trials
- Fibroblastic liposarcoma 0 trials
- Gastric liposarcoma 0 trials
- Intracranial liposarcoma 0 trials
- Kidney liposarcoma 0 trials
- Larynx liposarcoma 0 trials
- Liposarcoma of bone 0 trials
- Liposarcoma of the ovary 0 trials Sub-types →
- Mediastinum liposarcoma 0 trials
- Mixed liposarcoma 0 trials
- Pediatric liposarcoma 0 trials
- Vulvar liposarcoma 0 trials
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Angiosarcoma 37 trials · 82 incl. sub-types
19 sub-types
- Kaposi's sarcoma 45 trials Sub-types →
- Skin angiosarcoma 6 trials
- Breast angiosarcoma 1 trial
- Angiosarcoma of the scalp 0 trials
- Aorta angiosarcoma 0 trials
- Bone angiosarcoma 0 trials
- Central nervous system angiosarcoma 0 trials
- Conventional angiosarcoma 0 trials
- Gallbladder angiosarcoma 0 trials
- Liver angiosarcoma 0 trials
- Mediastinum angiosarcoma 0 trials
- Ovarian angiosarcoma 0 trials
- Pediatric angiosarcoma 0 trials
- Prostate angiosarcoma 0 trials
- Pulmonary artery leiomyosarcoma 0 trials
- Pulmonary vein leiomyosarcoma 0 trials
- Spleen angiosarcoma 0 trials
- Superior vena cava angiosarcoma 0 trials Sub-types →
- Thyroid gland angiosarcoma 0 trials
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Rhabdoid tumor 63 trials · 75 incl. sub-types
5 sub-types
- Atypical teratoid rhabdoid tumor 35 trials · 36 incl. sub-types Sub-types →
- Rhabdoid tumor of the kidney 7 trials
- Extrarenal rhabdoid tumor 1 trial
- Familial rhabdoid tumor 0 trials · 1 incl. sub-types Sub-types →
- Striated muscle rhabdoid tumor 0 trials
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Central nervous system sarcoma 2 trials · 74 incl. sub-types
12 sub-types
- Malignant peripheral nerve sheath tumor 36 trials · 38 incl. sub-types Sub-types →
- Atypical teratoid rhabdoid tumor 35 trials · 36 incl. sub-types Sub-types →
- Brain sarcoma 0 trials Sub-types →
- Central nervous system angiosarcoma 0 trials
- Central nervous system extraskeletal osteosarcoma 0 trials
- Central nervous system fibrosarcoma 0 trials
- Central nervous system leiomyosarcoma 0 trials Sub-types →
- Central nervous system rhabdomyosarcoma 0 trials
- Intracranial extraskeletal myxoid chondrosarcoma 0 trials
- Isolated melanotic schwannoma 0 trials
- Meningeal sarcoma 0 trials Sub-types →
- Spinal cord sarcoma 0 trials
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Leiomyosarcoma 62 trials · 72 incl. sub-types
31 sub-types
- Leiomyosarcoma of the corpus uteri 9 trials Sub-types →
- Ovary leiomyosarcoma 2 trials
- Retroperitoneal leiomyosarcoma 2 trials
- Inflammatory leiomyosarcoma 1 trial
- Small intestine leiomyosarcoma 1 trial
- Bone leiomyosarcoma 0 trials
- Breast leiomyosarcoma 0 trials
- Central nervous system leiomyosarcoma 0 trials Sub-types →
- Colon leiomyosarcoma 0 trials
- Conventional leiomyosarcoma 0 trials
- Cutaneous leiomyosarcoma 0 trials
- Epithelioid leiomyosarcoma 0 trials Sub-types →
- Esophagus leiomyosarcoma 0 trials
- Fallopian tube leiomyosarcoma 0 trials
- Gallbladder leiomyosarcoma 0 trials
- Gastric leiomyosarcoma 0 trials
- Heart leiomyosarcoma 0 trials
- Kidney leiomyosarcoma 0 trials
- Laryngeal leiomyosarcoma 0 trials
- Leiomyosarcoma of the cervix uteri 0 trials
- Liver leiomyosarcoma 0 trials Sub-types →
- Lung leiomyosarcoma 0 trials
- Mediastinum leiomyosarcoma 0 trials
- Myxoid leiomyosarcoma 0 trials Sub-types →
- Prostate leiomyosarcoma 0 trials
- Pulmonary artery leiomyosarcoma 0 trials
- Pulmonary vein leiomyosarcoma 0 trials
- Rectum leiomyosarcoma 0 trials Sub-types →
- Superior vena cava leiomyosarcoma 0 trials
- Vagina leiomyosarcoma 0 trials
- Vulvar leiomyosarcoma 0 trials
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Synovial sarcoma 53 trials
5 sub-types
- Biphasic synovial sarcoma 0 trials
- Breast synovial sarcoma 0 trials
- Fibrous synovial sarcoma 0 trials
- Mediastinum synovial sarcoma 0 trials
- Monophasic synovial sarcoma 0 trials Sub-types →
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Undifferentiated pleomorphic sarcoma 48 trials
3 sub-types
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Desmoplastic small round cell tumor 26 trials
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Myxofibrosarcoma 21 trials
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Fibrosarcoma 9 trials · 21 incl. sub-types
11 sub-types
- Dermatofibrosarcoma protuberans 11 trials Sub-types →
- Low grade fibromyxoid sarcoma 4 trials Sub-types →
- Conventional fibrosarcoma 0 trials · 2 incl. sub-types Sub-types →
- Pediatric fibrosarcoma 0 trials · 2 incl. sub-types Sub-types →
- Bone fibrosarcoma 0 trials
- Breast fibrosarcoma 0 trials
- Central nervous system fibrosarcoma 0 trials
- Heart fibrosarcoma 0 trials
- Kidney fibrosarcoma 0 trials
- Liver fibrosarcoma 0 trials
- Small intestinal fibrosarcoma 0 trials
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Alveolar soft part sarcoma 20 trials
2 sub-types
- Cervical alveolar soft part sarcoma 0 trials
- Vulvar alveolar soft part sarcoma 0 trials
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Epithelioid sarcoma 20 trials
4 sub-types
- Adult epithelioid sarcoma 0 trials
- Childhood epithelioid sarcoma 0 trials
- Peripheral epithelioid sarcoma 0 trials
- Proximal-type epithelioid sarcoma 0 trials Sub-types →
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Retroperitoneal sarcoma 17 trials
1 sub-type
- Retroperitoneal leiomyosarcoma 2 trials
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Clear cell sarcoma 14 trials · 16 incl. sub-types
1 sub-type
- Clear cell sarcoma of kidney 2 trials
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Liver sarcoma 1 trial · 10 incl. sub-types
7 sub-types
- Undifferentiated (embryonal) sarcoma 9 trials
- Bile duct sarcoma 0 trials Sub-types →
- Liver angiosarcoma 0 trials
- Liver extraskeletal osteosarcoma 0 trials
- Liver fibrosarcoma 0 trials
- Liver leiomyosarcoma 0 trials Sub-types →
- Liver rhabdomyosarcoma 0 trials Sub-types →
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Skin sarcoma 1 trial · 9 incl. sub-types
5 sub-types
- Skin angiosarcoma 6 trials
- Cutaneous undifferentiated pleomorphic sarcoma 2 trials
- Cutaneous leiomyosarcoma 0 trials
- Cutaneous liposarcoma 0 trials
- Skin lymphangiosarcoma 0 trials
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SMARCA4-deficient sarcoma of thorax 8 trials
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Kidney sarcoma 0 trials · 8 incl. sub-types
7 sub-types
- Rhabdoid tumor of the kidney 7 trials
- Clear cell sarcoma of kidney 2 trials
- Anaplastic sarcoma of the kidney 0 trials
- Kidney fibrosarcoma 0 trials
- Kidney leiomyosarcoma 0 trials
- Kidney liposarcoma 0 trials
- Kidney osteogenic sarcoma 0 trials
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Extraskeletal myxoid chondrosarcoma 7 trials
1 sub-type
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Intimal sarcoma 4 trials
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Extraskeletal Ewing sarcoma 3 trials
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Undifferentiated round cell sarcoma 3 trials
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Breast sarcoma 2 trials · 3 incl. sub-types
7 sub-types
- Breast angiosarcoma 1 trial
- Breast extraskeletal osteosarcoma 0 trials
- Breast fibrosarcoma 0 trials
- Breast leiomyosarcoma 0 trials
- Breast liposarcoma 0 trials
- Breast rhabdomyosarcoma 0 trials
- Breast synovial sarcoma 0 trials
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Extraosseous osteosarcoma 2 trials
7 sub-types
- Adult extraskeletal osteosarcoma 0 trials
- Breast extraskeletal osteosarcoma 0 trials
- Central nervous system extraskeletal osteosarcoma 0 trials
- Childhood extraosseous osteosarcoma 0 trials
- Kidney osteogenic sarcoma 0 trials
- Liver extraskeletal osteosarcoma 0 trials
- Mediastinal extraskeletal osteosarcoma 0 trials
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Ovarian sarcoma 0 trials · 2 incl. sub-types
4 sub-types
- Ovary leiomyosarcoma 2 trials
- Liposarcoma of the ovary 0 trials Sub-types →
- Ovarian angiosarcoma 0 trials
- Ovary rhabdomyosarcoma 0 trials
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Heart sarcoma 1 trial
3 sub-types
- Heart fibrosarcoma 0 trials
- Heart leiomyosarcoma 0 trials
- Malignant cardiac peripheral nerve sheath neoplasm 0 trials
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Small intestinal sarcoma 0 trials · 1 incl. sub-types
2 sub-types
- Small intestine leiomyosarcoma 1 trial
- Small intestinal fibrosarcoma 0 trials
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Testis sarcoma 0 trials · 1 incl. sub-types
1 sub-type
- Testis rhabdomyosarcoma 1 trial
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Anus sarcoma 0 trials
2 sub-types
- Anus leiomyosarcoma 0 trials
- Anus rhabdomyosarcoma 0 trials
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Bladder sarcoma 0 trials
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Esophagus sarcoma 0 trials
2 sub-types
- Esophagus leiomyosarcoma 0 trials
- Esophagus liposarcoma 0 trials
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Gallbladder sarcoma 0 trials
3 sub-types
- Gallbladder angiosarcoma 0 trials
- Gallbladder leiomyosarcoma 0 trials
- Gallbladder rhabdomyosarcoma 0 trials
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Laryngeal sarcoma 0 trials
2 sub-types
- Laryngeal leiomyosarcoma 0 trials
- Larynx liposarcoma 0 trials
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Lung sarcoma 0 trials
1 sub-type
- Lung leiomyosarcoma 0 trials
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Mediastinum sarcoma 0 trials
7 sub-types
- Malignant melanocytic peripheral nerve sheath tumor of mediastinum 0 trials
- Mediastinal extraskeletal osteosarcoma 0 trials
- Mediastinum angiosarcoma 0 trials
- Mediastinum leiomyosarcoma 0 trials
- Mediastinum liposarcoma 0 trials
- Mediastinum rhabdomyosarcoma 0 trials
- Mediastinum synovial sarcoma 0 trials
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Myxosarcoma 0 trials
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Pancreas sarcoma 0 trials
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Paranasal sinus sarcoma 0 trials
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Penile sarcoma 0 trials
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Prostate sarcoma 0 trials
4 sub-types
- Prostate angiosarcoma 0 trials
- Prostate leiomyosarcoma 0 trials
- Prostate rhabdomyosarcoma 0 trials Sub-types →
- Prostate stromal sarcoma 0 trials
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Stromal sarcoma 0 trials
1 sub-type
- Prostate stromal sarcoma 0 trials
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Thyroid sarcoma 0 trials
1 sub-type
- Thyroid gland angiosarcoma 0 trials
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Trachea sarcoma 0 trials
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Vagina sarcoma 0 trials
3 sub-types
- Endometrioid stromal sarcoma of the vagina 0 trials
- Vagina leiomyosarcoma 0 trials
- Vaginal rhabdomyosarcoma 0 trials Sub-types →
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Vulva sarcoma 0 trials
5 sub-types
- Vulvar alveolar soft part sarcoma 0 trials
- Vulvar childhood botryoid-type embryonal rhabdomyosarcoma 0 trials
- Vulvar leiomyosarcoma 0 trials
- Vulvar liposarcoma 0 trials
- Vulvar proximal-type epithelioid sarcoma 0 trials
Most studied deeper sub-types
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New combo therapy shows promise in early sarcoma trial
Disease control Stopped earlyThis study tests a new drug (ADI-PEG 20) combined with chemotherapy and radiation before surgery for soft tissue sarcoma. The goal is to find the safest dose and see how well it shrinks tumors. Only 6 patients with intermediate or high-grade sarcoma of the trunk or limbs are taki…
Phase 1 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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Early trial combines two chemo drugs with radiation for aggressive sarcomas
Disease control Stopped earlyThis Phase 1 trial tested a combination of two chemotherapy drugs (gemcitabine and docetaxel) given alongside radiation therapy for adults with large (over 5 cm), high-grade soft tissue sarcoma of the arms or legs. The goal was to find the safest dose and see how well the body to…
Phase 1 • Sponsor: Wake Forest University Health Sciences • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Experimental drug combo for rare sarcoma shows promise, but trial halted early
Disease control Stopped earlyThis phase 3 trial tested whether adding ADI-PEG 20 to standard chemotherapy (gemcitabine and docetaxel) could help people with advanced leiomyosarcoma, a rare soft tissue cancer. The study planned to enroll 218 participants whose cancer had progressed after prior treatment. Unfo…
Phase 3 • Sponsor: Polaris Group • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Experimental cell therapy targets Hard-to-Treat sarcoma
Disease control Stopped earlyThis phase 2 trial tested a new cell therapy called TAEST16001 in 8 adults with advanced soft tissue sarcoma that had stopped responding to standard treatments. The therapy uses specially engineered immune cells to attack cancer cells that carry a specific marker (NY-ESO-1) in pa…
Phase 2 • Sponsor: Sun Yat-sen University • Aim: Disease control
Last updated Jun 27, 2026 13:08 UTC
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New cocktail of cancer drugs tested in desperate cases
Disease control Stopped earlyThis early-phase trial tested combinations of the drugs bevacizumab and temsirolimus, sometimes with valproic acid or cetuximab, in 154 people with advanced cancers or certain non-cancerous but progressive diseases. The main goal was to find safe doses and look for any signs that…
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Experimental drug combo targets sarcoma before surgery
Disease control Stopped earlyThis early-stage trial tested a drug called AZD1390, which blocks DNA repair, given with or without an immunotherapy (durvalumab) plus standard radiation before surgery for soft tissue sarcoma. The goal was to see if the combination is safe and tolerable, especially regarding wou…
Phase 1 • Sponsor: The Netherlands Cancer Institute • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Experimental combo for rare sarcoma shows early promise but trial halted
Disease control Stopped earlyThis study tested a new drug called tazemetostat combined with standard chemotherapy (doxorubicin) in people with advanced epithelioid sarcoma, a rare soft-tissue cancer. The trial aimed to find a safe dose and see if the combination could help patients live longer without their …
Phase 1 • Sponsor: Epizyme, Inc. • Aim: Disease control
Last updated Jun 27, 2026 08:08 UTC
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Cancer-Fighting virus injected directly into tumors shows promise in early trial
Disease control Stopped earlyThis early-phase trial tested a new treatment called BT-001, a virus designed to infect and kill cancer cells, given alone or with the immunotherapy drug pembrolizumab. The study involved 31 people with advanced solid tumors like melanoma, lung cancer, or sarcoma that had spread.…
Phase 1/2 • Sponsor: Transgene • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Experimental cancer drug study halted early
Disease control Stopped earlyThis study tested an experimental drug called SQ3370 in 53 people with advanced solid tumors that had spread or could not be removed by surgery. The goal was to check the drug's safety and find the best dose, as well as see if it could shrink tumors. The study was terminated earl…
Phase 1/2 • Sponsor: Shasqi, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Experimental cancer drug LY3405105 fails to advance in early trial
Disease control Stopped earlyThis early-phase study tested the safety of an oral drug called LY3405105 in 54 people with advanced solid tumors. The trial was divided into two parts to find the right dose and to see if the drug could shrink tumors. However, the study was terminated early, meaning the drug did…
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Experimental cancer drug trial halted early
Disease control Stopped earlyThis early-stage study tested a new drug called HFB301001 in 31 adults with advanced solid tumors (like sarcoma, kidney cancer, or melanoma) that had not responded to prior treatments. The main goal was to check the drug's safety and find the best dose. The study was terminated, …
Phase 1 • Sponsor: HiFiBiO Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Sarcoma lung surveillance study halted early: x-ray vs CT debate unresolved
Knowledge-focused Stopped earlyThis study aimed to compare chest X-ray and CT scans for detecting lung metastases in people who had surgery for high-grade soft tissue sarcoma. Only 11 patients were enrolled before the study was terminated early. The goal was to see which method better finds isolated, operable …
Phase 2 • Sponsor: Centre Oscar Lambret • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Sarcoma patients share their experience on a second chemo round
Knowledge-focused Stopped earlyThis study aimed to track how soft tissue sarcoma patients feel—symptoms, side effects, and quality of life—when they receive trabectedin chemotherapy again after a break. Only 7 patients were enrolled before the study was stopped early. The goal was to gather real-world patient …
Sponsor: Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC