Small intestinal bacterial overgrowth
MONDO:0400000The presence of excessive bacteria in the small intestine that can result from result from failure of the gastric acid barrier, failure of small intestinal motility, anatomic alterations, or impairment of systemic and local immunity.
Also known as: SIBO
48 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Simple drug may cut infection risk after major gut surgery
Disease control CompletedThis study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …
Phase: PHASE4 • Sponsor: Bayside Health • Aim: Disease control
Last updated Jun 27, 2026 08:07 UTC
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Can probiotics boost antibiotic success against gut bacteria overgrowth?
Disease control CompletedThis study looked at whether taking probiotic supplements alongside the antibiotic rifaximin helps people with SIBO feel better. 129 adults with bloating or constipation took either probiotics or a placebo for 3 months. The goal was to see if the combination reduced symptoms and …
Phase: NA • Sponsor: Pomeranian Medical University Szczecin • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Rural patients get Hospital-Level care at home in landmark trial
Disease control CompletedThis study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…
Phase: NA • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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New rapid test for infection and inflammation put to the test
Diagnosis CompletedThis study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…
Sponsor: LumiraDx UK Limited • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Which scope is safer for kids? new study compares balloon enteroscopy methods
Diagnosis CompletedThis study looked at 208 children who had a procedure called balloon enteroscopy to find problems in the small intestine. Researchers compared two types—single-balloon and double-balloon—to see which one worked better and was safer. The goal was to help doctors choose the best me…
Sponsor: Shandong University • Aim: Diagnosis
Last updated Jun 27, 2026 09:05 UTC
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New PET scan technique aims to sniff out hidden infections
Diagnosis CompletedThis early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…
Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Jun 27, 2026 08:03 UTC
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Could a daily supplement soothe SIBO? small trial tests safety
Symptom relief CompletedThis pilot study tested an 8-week course of a multi-ingredient nutritional supplement (AV1PD1A) in 9 adults with hydrogen-dominant small intestinal bacterial overgrowth (SIBO). The main goal was to see if the supplement was safe and tolerable. Participants took three capsules dai…
Phase: NA • Sponsor: National University of Natural Medicine • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Can an online wellness program ease anxiety in chronic disease?
Symptom relief CompletedThis study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…
Phase: NA • Sponsor: University of Alberta • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Low FODMAP diet eases gut troubles in SIBO patients
Symptom relief CompletedThis study looked at whether a low FODMAP diet (LFD) can reduce stomach symptoms and improve nutrition in people with small intestinal bacterial overgrowth (SIBO). 51 adults who had finished antibiotic treatment were split into two groups: one followed the LFD, the other ate norm…
Phase: NA • Sponsor: Warsaw University of Life Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Scientists map gut bugs in double infection
Knowledge-focused CompletedThis study looked at 42 adults with both H. pylori infection and small intestinal bacterial overgrowth (SIBO). Researchers used advanced DNA and chemical tests on stool samples to map the types of gut bacteria and their byproducts. The goal was to better understand how these two …
Sponsor: Zhongshan Hospital (Xiamen), Fudan University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Breath test reveals gut bacteria changes after Weight-Loss surgery
Knowledge-focused CompletedThis study looked at how gastric bypass surgery changes the bacteria in the small intestine. Researchers measured hydrogen in the breath of 51 severely obese patients before surgery and at several points up to 2 years after. The goal was to find out how often bacterial overgrowth…
Phase: NA • Sponsor: Lille Catholic University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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ICU antibiotic dosing: what really matters?
Knowledge-focused CompletedThis study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Capsule camera data could sharpen disease detection
Knowledge-focused CompletedThis completed observational study collected over 3,700 PillCam SB3 capsule endoscopy videos from standard care procedures. The goal was to build a large database of images showing both normal and diseased small intestine tissue. Researchers will use this data to develop and vali…
Sponsor: Medtronic - MITG • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC