Skin neoplasm

This study tested a new approach for people with advanced melanoma that can be surgically removed. Participants received a combination of two immunotherapies: one injected directly into the tumor (Tavo) and one given through a vein (nivolumab). After 12 weeks, they had surgery to…

This early-stage study tested an experimental drug called JCXH-211, which is injected directly into tumors. It involved 19 adults with advanced solid tumors that had not responded to standard treatments. The main goals were to check safety and find the right dose, while also watc…

This early pilot study tested a new radioactive bandage called CivaDerm on 10 people with common skin cancers (basal cell or squamous cell carcinoma). The bandage delivers radiation directly to the skin surface, aiming to destroy cancer cells while sparing healthy tissue. The stu…

This phase 3 trial tested a combination of two targeted drugs, LGX818 and MEK162, against standard treatments in 921 people with advanced melanoma that has a BRAF V600 mutation. The study compared the combo to vemurafenib alone or LGX818 alone to see which worked better at delayi…

This study looked at kidney transplant patients who already had one skin cancer. It compared switching their anti-rejection medicine to rapamycin versus staying on standard drugs. The goal was to see if rapamycin could prevent new skin cancers over two years while keeping the tra…

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…

This study tested an experimental treatment for metastatic melanoma using a patient's own immune cells (tumor-infiltrating lymphocytes) grown in a lab and given back along with high-dose IL-2. Before the cell infusion, all patients received chemotherapy to suppress their immune s…

This pilot study tested a new combination treatment for people with advanced melanoma that has spread. It combined a patient's own immune cells grown in a lab (called TILs) with an immunotherapy drug called ipilimumab. The main goals were to see if the treatment was safe and poss…

This study tested whether taking a daily pill called sonidegib for 12 weeks could shrink basal cell carcinomas in cosmetically sensitive areas like the face. The goal was to make surgery less invasive, reduce scarring, or even avoid surgery altogether by using only a topical crea…

This study tested whether a second round of treatment with tiny radioactive seeds (DaRT) could safely shrink or control skin, mouth, or soft tissue cancers that came back after the first treatment. Only 2 people took part, and researchers measured tumor response and side effects.…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This trial tests a workplace program designed to encourage local government organizations to adopt sun protection policies for outdoor workers. The program provides education and resources to managers and employees, aiming to increase the use of sun-safe practices. Researchers wi…

This completed study tested a school-based educational program to improve sun protection among 38 rural Utah high school students. The program included a 90-minute session with skin cancer education, a risk self-assessment, and creating a personal sun protection plan. Surveys mea…

This trial tested a virtual learning program called SSW Works, designed to help outdoor workers protect themselves from the sun. Over 500 workers and their managers participated. The program provided culturally tailored tips on sunscreen, clothing, and shade use. Researchers meas…

This study looked at whether giving people personalized information about their genetic risk for melanoma could encourage them to protect themselves from the sun. Over 2,000 adults received either standard sun safety tips or tailored advice based on their DNA. Researchers then tr…

This study tested a program called SHINE to help high school students use more sun protection and tan less. Over 2,200 students from 30 schools in Utah took part. Half the schools got the SHINE program, and the other half got standard lessons. The goal was to see if the program c…

This study tested whether smelling lavender essential oil during Mohs surgery for skin cancer can reduce patient anxiety and mask unpleasant odors. 89 adults having surgery on their head or neck took part. Researchers measured anxiety using standard questionnaires and asked about…

This study measured anxiety in 100 patients undergoing Mohs surgery for skin cancer. Researchers compared anxiety levels between first-time and returning patients, and also tested whether reading a short story about a typical patient's experience helped reduce anxiety. The goal i…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study looks at how satisfied people are after having skin cancer surgery. Researchers ask patients to rate their experience with the surgeon, the facility, the procedure itself, and their recovery. The goal is to understand what matters most to patients and find ways to impr…

This study enrolled 500 skin cancer patients in China and analyzed over 1.2 million of their social media posts using artificial intelligence. The goal was to see if AI could detect signs of psychological distress and suicidal thoughts. Researchers hope this approach could lead t…

This study tested a simple photo-based method to measure changes in nose shape and size after skin cancer surgery. Researchers took before-and-after photos of 68 patients who had surgery for common skin cancers. The goal was to see if this photographic approach could be a reliabl…

This completed study looked at 132 people with advanced melanoma to see if levels of a protein called interferon-gamma (IFN-γ) in their tumors or blood could predict how well they would respond to first-line immunotherapy drugs like pembrolizumab, nivolumab, or a combination. The…

This study tested whether an artificial intelligence (AI) tool could help primary care doctors more accurately diagnose skin conditions and decide which patients need to see a skin specialist. 131 adults with various skin issues, including possible skin cancer, took part. Doctors…

This completed study tested a smartphone app that gave parents and kids real-time tips on sun protection. 78 families with children aged 8-17 took part. The goal was to see if the app could help kids use more sunscreen and protective clothing and get fewer sunburns.

This study looked at how 78 patients with high-risk skin cancer on the head or neck felt about their treatment decisions, quality of life, and satisfaction with care. Researchers used standard questionnaires to measure these factors at two points: right after a team of doctors di…

This completed study tested whether teaching parents about skin cancer, self-exams, and sun protection would improve their children's sun safety. Researchers gave 300 parents of 10-14 year olds either training with brochures or no training. They measured changes in parents' knowl…

This study tested whether combining two noninvasive techniques—a special skin scan (OCT) and sticky tape that collects skin cells—can accurately detect basal cell carcinoma, a common skin cancer. Fifty adults with suspected BCC were scanned and had tape strips taken from the same…

This study looked at whether certain vitamin D receptor gene variations are linked to non-melanoma skin cancer risk in an Alabama population. Researchers compared 200 people aged 50 and older, some with skin cancer and some without, by analyzing their DNA from blood samples. The …