Rheumatic heart disease
MONDO:0006955An autoinflammatory condition following an infection with Group A Beta Hemolytic Streptococcus (GABHS), in which the heart is attacked by antibodies formed in reaction to a recent GABHS infection. Chief anatomic changes of the valve include leaflet thickening, commissural fusion, and shortening and thickening of the tendinous cords, all of which can result in valvular dysfunction.
Also known as: RHD, disease, rheumatic heart, heart disease, rheumatic, rheumatic carditis
13 clinical trials for this condition and its sub-types.
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Broader categories
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Pill vs. needle: can a daily penicillin pill prevent heart damage in kids?
Disease control OngoingThis study looks at whether taking penicillin twice a day by mouth works as well as getting a penicillin shot every month to stop latent rheumatic heart disease from getting worse. About 1,000 children aged 5 to 17 with early signs of the disease are taking part. The goal is to f…
Phase: PHASE2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could a simple heart scan save mothers and babies?
Diagnosis OngoingThis study tests whether giving pregnant women a heart ultrasound during routine check-ups can catch hidden heart problems and reduce risks like death, heart failure, or low baby health scores. About 9,000 women in Nepal will be randomly assigned to receive the ultrasound or stan…
Phase: NA • Sponsor: Thomas Pilgrim • Aim: Diagnosis
Last updated Jun 27, 2026 08:12 UTC