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Respiratory failure
MONDO:0021113The significant impairment of gas exchange within the lungs resulting in hypoxia, hypercarbia, or both, to the extent that organ tissue perfusion is severely compromised. Causes include chronic obstructive pulmonary disease, asthma, emphysema, acute respiratory distress syndrome, pneumonia, pulmonary edema, pneumothorax, and congestive heart failure. Treatment requires intubation and mechanical ventilation until the time the lungs recover sufficient function.
Also known as: failure, respiratory, respiratory failure, acute respiratory failure, chronic respiratory failure, acute and chronic respiratory failure, acute-on-chronic respiratory failure
790 clinical trials for this condition and its sub-types, 280 tagged with Respiratory failure itself.
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Sub-types of Respiratory failure
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Acute respiratory failure 153 trials · 588 incl. sub-types
3 sub-types
- Acute respiratory distress syndrome 298 trials · 417 incl. sub-types Sub-types →
- Pulmonary edema 27 trials · 32 incl. sub-types Sub-types →
- Neonatal respiratory failure 13 trials
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Respiratory paralysis 20 trials
Most studied deeper sub-types
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Smart oxygen machine aims to get COPD patients out of hospital faster
Disease control Stopped earlyThis study tested a device called FreeO2 that automatically adjusts oxygen levels for people hospitalized with a COPD flare-up. The goal was to see if it could shorten hospital stays compared to manual oxygen adjustment by staff. Only 17 people took part, and the study was stoppe…
Sponsor: Laval University • Aim: Disease control
Last updated Jun 26, 2026 14:17 UTC
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Could skipping the chest tube after lung surgery cut pain and hospital time?
Symptom relief Stopped earlyThis trial investigates whether removing the chest tube during thoracoscopic lung surgery, instead of leaving it in place afterward, leads to less pain and faster recovery. Participants undergoing elective wedge resection are randomly assigned to have the tube removed during surg…
Sponsor: Rigshospitalet, Denmark • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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Breathing machine showdown: which mode helps obese patients best?
Symptom relief Stopped earlyThis study compared two types of non-invasive breathing support for people with sudden breathing failure who are obese or have sleep apnea. One machine automatically adjusts pressure and volume, while the other uses a fixed pressure setting. The goal was to see which method clear…
Sponsor: University Hospital, Rouen • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Breathing vest tested for hospital patients – but study stopped early
Symptom relief Stopped earlyThis study tested a negative pressure vest (Biphasic Cuirass Ventilation) to see if it works as well as standard breathing masks for patients hospitalized with acute hypercapnic respiratory failure (high carbon dioxide levels). The trial planned to enroll 50 adults, but it was te…
Sponsor: University of Missouri-Columbia • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Nasal High-Flow device tested for breathing trouble
Symptom relief Stopped earlyThis study tested a device that delivers warm, moist air through the nose to help people with breathing failure who did not have too much acid in their blood. The goal was to see if it could prevent their condition from getting worse. Only 16 people took part, and the study was s…
Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Can new home monitors keep tabs on breathing support without a clinic visit?
Knowledge-focused Stopped earlyThis trial tests two new devices, NivolisMonitor and NivolisAnton, designed for people who use breathing support at home, such as non-invasive ventilation or high-flow nasal oxygen. NivolisMonitor measures breathing parameters like pressure, flow, and oxygen levels, while Nivolis…
Sponsor: VIVARDIS • Aim: Knowledge-focused
Last updated Sep 04, 2026 00:00 UTC
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Anesthesia drug study halted after just 3 patients
Knowledge-focused Stopped earlyThis study aimed to see if skipping a type of muscle relaxant during general anesthesia could lower the risk of serious lung complications in high-risk surgery patients. The trial was terminated early after enrolling only 3 participants, so no meaningful conclusions can be drawn.…
Phase 4 • Sponsor: Beth Israel Deaconess Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Ventilator weaning study for obese patients halted early
Knowledge-focused Stopped earlyThis study tested if a special measurement called transpulmonary pressure could help obese patients with breathing failure get off ventilators sooner. Only 4 people took part before the study was stopped early. The goal was to reduce time on the ventilator and lower risks like in…
Sponsor: University of Mississippi Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Smart band tracks COVID-19 breathing trouble
Knowledge-focused Stopped earlyThis study tested a special band called AirGo to monitor breathing patterns in hospitalized COVID-19 patients with respiratory failure. The goal was to see if the band could detect early signs of worsening breathing, helping doctors decide when to use a breathing tube. The study …
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:55 UTC
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Ventilator showdown: which mode helps ICU patients breathe better?
Knowledge-focused Stopped earlyThis study looked at two different ways to use a breathing machine (ventilator) for patients in the intensive care unit who have dangerously low oxygen levels. The goal was to measure pressure inside the lungs with each method to see which might be safer or more effective. The st…
Sponsor: University Hospital Bispebjerg and Frederiksberg • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:48 UTC