Reactive cutaneous fibrous lesion

This Phase 2 trial tests whether small interfering RNA (siRNA) microneedle patches can improve the appearance of earlobe keloid scars after laser surgery. About 158 adults with earlobe keloids will receive either standard steroid injections alone or steroid injections plus the si…

This study compares two silicone gel formulations, Dermatix and Dermatix Ultra, to see if one is better at improving the appearance and symptoms of raised scars (keloids and hypertrophic scars). About 150 people with existing or new scars will use one of the gels twice daily for …

This study tests a new approach for treating keloids—thick, raised scars that can be painful and itchy. The treatment combines wide-band ultrasound with a traditional Chinese medicine preparation applied to the skin. The goal is to soften scar tissue, reduce symptoms, and prevent…

This study tests if injecting polidocanol (a medicine that reduces blood flow) into keloids and hypertrophic scars can make them flatter and less noticeable. About 90 people with scars that are less than a year old will receive either polidocanol or a standard steroid injection. …

This study looks at whether removing keloids surgically and then applying a radioactive patch (32P) can prevent them from returning. About 401 people with keloids will get this treatment and be checked every 6 months for 2 years. The goal is to see how well the combo works and wh…

This study tests if a drug called bleomycin works better than the usual combination of 5-FU and triamcinolone for shrinking keloids (raised scars). About 104 people aged 13-60 with keloids will receive injections into their scars. Researchers will measure scar improvement over 12…

This study will see if adding a cold plasma device to standard scar care helps improve scars like keloids, burn scars, and acne scars. About 800 people will take part, with half getting standard care plus plasma and half standard care alone. Researchers will track changes in scar…

This study compares two treatments for keloids (raised scars that grow beyond the original wound). One group gets a special freezing treatment inside the scar (intralesional cryosurgery) alone. The other group gets the same freezing plus an injection of two medicines (5-fluoroura…