Radioulnar synostosis-developmental delay-hypotonia syndrome
MONDO:0009952Radioulnar synostosis-developmental delay-hypotonia syndrome, also known as Der Kaloustian-McIntosh-Silver syndrome, is an extremely rare syndrome with synostosis described in about 4 patients to date with clinical manifestations including congenital unilateral radioulnar synostosis, generalized hypotonia, developmental delay, and dysmorphic facial features (long face, prominent nose and ears).
Also known as: Der Kaloustian-McIntosh-Silver syndrome, radioulnar synostosis with developmental delay and hypotonia syndrome, der Kaloustian mcintosh silver syndrome, radioulnar synostosis, unilateral, with developintellectual disability and hypotonia, radioulnar synostosis, unilateral, with developmental retardation and hypotonia, unilateral radio-ulnar synostosis, generalised hypotonia, developintellectual disability, and a characteristic facial appearance, unilateral radio-ulnar synostosis, generalised hypotonia, developmental retardation, and a characteristic facial appearance, unilateral radio-ulnar synostosis, generalized hypotonia, developintellectual disability, and a characteristic facial appearance
18 clinical trials for this condition and its sub-types.
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Zapping aggression: could a headset tame impulsive outbursts?
Disease control Recruiting nowThis clinical trial is testing whether a non-invasive brain stimulation technique called transcranial direct current stimulation (tDCS) can reduce impulsivity and aggression in adults with developmental disabilities. The study will involve 60 participants who have a developmental…
Phase: NA • Sponsor: Dr. Najat Khalifa • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Pre-dental video call may ease clinic visits for patients with special needs
Symptom relief Recruiting nowThis study tests whether a short telehealth interview 3-7 days before a dental checkup helps patients with intellectual or developmental disabilities (IDD) have a smoother visit. About 50 youth with IDD and their caregivers will be randomly assigned to receive the telehealth call…
Phase: NA • Sponsor: Boston University • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New coaching method aims to curb tantrums and aggression in kids with delays
Symptom relief Recruiting nowThis study tests a personalized coaching program for parents and early intervention professionals to reduce problem behaviors like aggression and screaming in children up to 5 years old with developmental delays. Researchers will observe and track changes in behavior during short…
Phase: NA • Sponsor: University of Nevada, Las Vegas • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Can coaching parents boost social skills in kids with disabilities?
Symptom relief Recruiting nowThis study tests whether a speech therapy that involves parents can improve early social and communication skills in children aged 6 months to 5 years with neurodevelopmental disabilities. One group gets the parent-focused therapy, while the other gets standard speech therapy. Re…
Phase: NA • Sponsor: IRCCS Eugenio Medea • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Which early intervention method works best for toddlers with delays?
Knowledge-focused Recruiting nowThis study tests three different approaches to speech therapy for toddlers with developmental delays. About 1,269 children will receive either therapist-led sessions, caregiver coaching, or a combination of both. The goal is to find which method helps children and families the mo…
Phase: NA • Sponsor: Northwestern University • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC