Radiodermatitis

This Phase 2 trial tested whether oral cimetidine (Tagamet), a common heartburn drug, can reduce light sensitivity in people with erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP). These genetic conditions cause severe pain from sunlight exposure. The study en…

This completed study tested two older, low-cost drugs—methotrexate and azathioprine—against chronic actinic dermatitis, a painful skin reaction to sunlight. Fifty adults were randomly assigned to one drug for 24 weeks. Researchers tracked eczema severity and safety. The goal was …

This study tested special clothing made with Lumiton yarn that captures sunlight and turns it into red and near-infrared light, aiming to improve skin conditions like psoriasis, alopecia areata, and polymorphous light eruption. Eighteen adults with mild-to-severe forms of these c…

This study tested whether hyperbaric oxygen therapy (HBOT) can help heal severe tissue damage caused by past radiation treatment. 39 adults who had radiotherapy and developed serious radiation injuries received HBOT sessions in a pressurized chamber while breathing pure oxygen. T…

This Phase 3 trial tests whether wearing a hydrogel bandage on the skin of the head and neck during radiation therapy can reduce pain and skin irritation in people with head and neck cancer. About 130 participants will either wear the bandage for at least 5 hours a day during tre…

This trial tests whether a cream made with mushroom extracts can help protect the skin of women undergoing radiation therapy for breast cancer. Participants use the cream or a standard moisturizer on the treated breast twice daily, starting before radiation and continuing for a m…

This pilot study tests whether a special cream (KeraStat) and a mobile app (MyCap) can help manage skin rashes caused by radiation therapy in head and neck cancer patients. Sixteen participants will apply the cream at least twice daily during radiation and use the app to report t…

This study tested a silver-plated wound dressing (Silverlon) in 17 breast cancer patients receiving radiation therapy. The goal was to see if the dressing could reduce the severity of acute radiation dermatitis, a common skin reaction that causes redness, peeling, and pain. Patie…

This study tested a special dressing coated with a substance that binds bacteria (DACC-coated hydrogel) to treat skin burns caused by radiation therapy in 18 women with breast cancer. The goal was to see if it could reduce pain and help heal the skin. The study is already complet…

This study tested whether a gel made from birch bark extract (Oleogel-S10) can help heal skin burns caused by radiation therapy in breast cancer patients. 18 women with moderate to severe radiation dermatitis used the gel along with a standard steroid cream. The goal was to see i…

This study looked at whether a morphine gel can help with pain from severe radiation-induced skin irritation (radiodermatitis) in the perineal area. Researchers reviewed records of 17 patients who used the gel. The goal was to see if pain decreased and if it helped avoid breaks i…

This study tested two skin treatments—a hydrogel dressing and a water spray—for women with breast cancer who developed skin irritation from radiotherapy. The goal was to see which one better prevented treatment delays or the need to switch care. 278 women with mild to moderate sk…