Primary angle-closure glaucoma
MONDO:0001868An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
24 clinical trials for this condition and its sub-types.
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Broader categories
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New eye implant could reduce glaucoma drops
Disease control CompletedThis study tested a small implant called Supraflow v2.2 in 57 adults with open-angle or narrow-angle glaucoma. The implant is placed inside the eye to help drain fluid and lower eye pressure. The goal was to see if it safely reduces pressure and the need for daily eye drops over …
Phase: NA • Sponsor: Ciliatech • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New 'Micro' eye surgery could ease glaucoma treatment
Disease control CompletedThis study tested a new, less invasive surgery called MIMS for people with glaucoma. The goal was to see if it lowers eye pressure as well as traditional surgery but with fewer side effects. 23 adults with glaucoma took part. The results will help doctors understand if MIMS is a …
Phase: NA • Sponsor: Hôpital Privé de la Baie • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Warm IV fluid eases pain for emergency eye patients
Symptom relief CompletedThis study tested whether warming the intravenous (IV) mannitol fluid before giving it to people with sudden high eye pressure can reduce pain and improve comfort. 142 adults took part, with half getting warmed mannitol and half getting standard (room temperature) mannitol. The g…
Phase: NA • Sponsor: Joint Shantou International Eye Center of Shantou University and the Chinese University of Hong Kong • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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App aims to clear up glaucoma drop confusion
Knowledge-focused CompletedThis study tested whether a simple app, available in English, Spanish, and Cantonese, could help glaucoma patients better remember their multiple eye drop schedules. Twenty participants either used the app or received standard instructions. After one month, researchers compared h…
Phase: NA • Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC