Primary angle-closure glaucoma
MONDO:0001868An angle-closure glaucoma characterized by closure of the anterior chamber angle by an intrinsic defect such that aqueous outflow is blocked and the intraocular pressure becomes inappropriately elevated leading to optic nerve damage and visual field loss. Primary angle-closure glaucoma has symptom progressive peripheral vision loss, decreased vision, and pain, redness, and headache in acute cases. Primary angle closure glaucoma can be caused by anatomically narrow angle, defects in the trabecular meshwork, and iris abnormalities. Primary angle-closure glaucoma has a strong genetic component.
20 clinical trials for this condition and its sub-types.
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Broader categories
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Can a tiny eye implant replace glaucoma drops?
Disease control Not yet recruitingThis trial tests a new device called VividFlo, a small implant placed under the eye's surface to help drain fluid and lower pressure in people with glaucoma. The study involves 10 adults with glaucoma in one eye, who will receive the implant during surgery. Researchers will track…
Phase: NA • Sponsor: VividWhite Pty Ltd • Aim: Disease control
Last updated Aug 12, 2026 00:00 UTC
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Which eye implant best tames glaucoma? a head-to-head trial aims to find out.
Disease control Not yet recruitingThis trial compares two surgical implants—the Baerveldt Glaucoma Implant and the Paul Glaucoma Implant—in people with glaucoma that is not well controlled by eye drops. Both devices are tiny tubes placed in the eye to drain fluid and lower pressure. The study will track which imp…
Phase: PHASE4 • Sponsor: University of Sydney • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Could a simple home workout protect eyesight in glaucoma?
Disease control Not yet recruitingThis trial investigates whether a 12-week home-based circuit training program can reduce intraocular pressure and improve retinal health in people with glaucoma. Participants are randomly assigned to either the exercise program plus standard care or standard care alone. The study…
Phase: NA • Sponsor: Universiti Sains Malaysia • Aim: Disease control
Last updated Aug 01, 2026 00:00 UTC
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Could a daily reading drill restore lost reading skills in glaucoma?
Symptom relief Not yet recruitingThis trial tests whether a structured reading rehabilitation module can improve reading speed and reduce errors in people with glaucoma, a condition that often impairs vision. Participants will practice the module for 20-30 minutes daily, at least 3 days a week, for 6 months. The…
Phase: NA • Sponsor: Universiti Sains Malaysia • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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New study aims to predict rare eye complication after glaucoma surgery
Knowledge-focused Not yet recruitingThis study looks at people with primary angle-closure glaucoma who need a specific type of eye surgery. The goal is to find out which patients are at higher risk for a rare but serious complication called ciliary block, where fluid builds up in the wrong part of the eye. Research…
Sponsor: Peking University People's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC