Premenstrual dysphoric disorder

This study tests whether a small, wearable device that gently stimulates nerves in the ear can improve mood and physical symptoms in women with premenstrual dysphoric disorder (PMDD) or perimenopause. Participants use the device daily and report their symptoms through online surv…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study looks at whether women with premenstrual dysphoric disorder (PMDD) have different levels of the hormones progesterone and estrogen in the week after ovulation compared to women without PMDD. Researchers will take a single blood sample about 7 days after ovulation and m…

This study from Johns Hopkins aims to find epigenetic markers in blood that could help identify premenstrual dysphoric disorder (PMDD). Researchers will collect blood samples and track mood changes across the menstrual cycle in 500 women — some with PMDD and some without. The goa…

This study looks at how brain chemicals called neuroactive steroids change across the menstrual cycle in women with Premenstrual Dysphoric Disorder (PMDD) compared to healthy women. It also tests whether a low-dose antidepressant (sertraline) affects these chemical levels. The go…

This study compares women with PMDD, major depressive disorder (MDD), and healthy controls to see how their brains, stress responses, and inflammation differ. Researchers will use brain scans, stress tasks, and blood/saliva tests in 75 naturally cycling women aged 18-40. The goal…