Premature menopause
MONDO:0001119Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive.
Also known as: POF, early menopause, premature menopause, premature ovarian failure
28 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Sister's ovary tissue may restore fertility in early menopause
Disease control Not yet recruitingThis study tests whether transplanting ovarian tissue from a sister can restore fertility and hormone production in women with premature ovarian failure (early menopause). Ten women will receive tissue from their non-identical sister, along with immunosuppressive drugs to prevent…
Phase: NA • Sponsor: Rebecca Flyckt • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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Acupuncture offers Drug-Free hope for BRCA carriers suffering hot flashes
Symptom relief Not yet recruitingThis study tests whether acupuncture, with or without daily self-acupressure, can reduce hot flashes in women with BRCA gene mutations who had their ovaries removed. About 200 participants will receive 8 weekly acupuncture sessions, then half will also practice acupressure at hom…
Phase: NA • Sponsor: Shaare Zedek Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Massive new registry to track menopause health in 5,000 women
Knowledge-focused Not yet recruitingThis study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Can estrogen protect hearts in early menopause? new study aims to find out
Knowledge-focused Not yet recruitingThis observational study will follow 45 women with primary ovarian insufficiency (POI)—a condition that causes early menopause—who are starting estrogen replacement therapy. Researchers will measure heart health markers before and after 6 months of treatment and compare them to h…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC