Premature menopause
MONDO:0001119Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive.
Also known as: POF, early menopause, premature menopause, premature ovarian failure
21 clinical trials for this condition and its sub-types.
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Can a blood injection reboot ovaries? small trial tests PRP for fertility
Disease control OngoingThis study tests whether injecting a woman's own platelet-rich plasma (PRP) into the ovary can help restore function in women with premature ovarian insufficiency (early menopause). 35 women under 40 will receive PRP in one ovary and a saline placebo in the other. The main goal i…
Sponsor: ART Fertility Clinics LLC • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Can stem cells restore fertility in early menopause?
Disease control TerminatedThis study tests whether stem cells from umbilical cords can safely help women with premature ovarian failure (early menopause). Twelve participants receive stem cell infusions, and doctors monitor menstrual cycles, hormone levels, and follicle growth. The goal is to see if this …
Phase: PHASE2 • Sponsor: Sclnow Biotechnology Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Stem cell shot into ovaries aims to tame perimenopause symptoms
Disease control ENROLLING_BY_INVITATIONThis study looks at whether injecting special stem-like cells called Muse cells directly into the ovaries can help women aged 28 to 70 who are in perimenopause. The cells may repair tissue, reduce inflammation, and improve hormone balance. Researchers will track safety, hormone l…
Sponsor: Healing Hope International • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Ovarian graft could spare young cancer patients from early menopause
Disease control OngoingThis early-phase trial tests whether moving a piece of a woman's own ovary to the fatty tissue of her inner thigh before pelvic radiation can keep her ovaries working. The study includes 22 women aged 35 or younger with locally advanced cervical cancer. The goal is to see if the …
Phase: PHASE1, PHASE2 • Sponsor: MARILIA ALBANEZI BERTOLAZZI • Aim: Disease control
Last updated Jun 26, 2026 14:04 UTC
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Gut bugs linked to early menopause?
Knowledge-focused OngoingThis study looks at gut bacteria in 30 women with premature ovarian failure and 30 healthy women. Researchers compare stool and blood samples to see if differences in gut microbes are tied to hormone levels. The goal is to learn more, not to test a treatment.
Phase: EARLY_PHASE1 • Sponsor: Songling Zhang • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New study tracks ovarian health after chemo in young women
Knowledge-focused OngoingThis study follows 196 women aged 11-35 who are receiving chemotherapy for cancer. Researchers measure hormone levels and ovarian follicles before, during, and after treatment to see how the ovaries are affected. The goal is to better understand the risk of early menopause and fe…
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC