Ovarian graft could spare young cancer patients from early menopause

NCT ID NCT05462379

Ongoing Disease control Sponsor: MARILIA ALBANEZI BERTOLAZZI Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This early-phase trial tests whether moving a piece of a woman's own ovary to the fatty tissue of her inner thigh before pelvic radiation can keep her ovaries working. The study includes 22 women aged 35 or younger with locally advanced cervical cancer. The goal is to see if the graft produces enough hormones to prevent early menopause, offering a simpler and cheaper alternative to hormone replacement therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ovarian tissue graft (autologous heterotopic fresh ovarian graft)
What this could lead to: If it works, this could offer a way for young women with cervical cancer to keep their natural hormone production after pelvic radiation, avoiding early menopause without needing hormone replacement therapy.
What could go wrong: This is an early phase 1-2 trial with only 22 participants, so results are preliminary. The graft may not produce enough hormones, and there are risks from surgery and the graft itself.

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Conditions

The condition(s) this trial relates to.

cervical cancer cervical carcinoma premature menopause primary ovarian failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOCALLY ADVANCED CERVICAL CARCINOMA PREMATURE OVARIAN FAILURE

Contacts and locations

Locations

Instituto do Cancer do Estado de São Paulo

São Paulo, 01246-000, Brazil

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