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Premature menopause
MONDO:0001119Cessation of menstruation before the age of 40. Symptoms include hot flashes, night sweats, mood swings, and decreased sex drive.
Also known as: POF, early menopause, premature menopause, premature ovarian failure
28 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Stem cell gene therapy for early menopause: 2.5-Year Follow-Up shows promise
Disease control CompletedThis study followed 86 women under 40 with premature ovarian failure (early menopause) who had received a one-time gene therapy using their own stem cells. The goal was to check long-term safety and see if hormone levels and fertility improved over 2.5 years. No new treatment was…
Sponsor: Ukraine Association of Biobank • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Cord blood plasma could repair thin uterine lining
Disease control CompletedThis study tested whether platelet-rich plasma from umbilical cord blood can thicken the endometrium (uterine lining) in women with Asherman's syndrome or endometrial atrophy. Fifteen women received an injection of the plasma into the uterine wall during a hysteroscopy, along wit…
Phase: PHASE2 • Sponsor: Fundación IVI • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New online program boosts sexual health for young breast cancer survivors
Symptom relief CompletedThis study tested an online nurse-led program to help young women who had breast cancer improve their sexual health, body image, and menopausal symptoms. 43 women who finished treatment within the last five years took part in eight weekly sessions. The program aimed to see if it …
Phase: NA • Sponsor: University of Arkansas • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Could an antidepressant tame hot flashes without hormones?
Symptom relief CompletedThis study tested whether paroxetine, a common antidepressant, can reduce hot flashes and night sweats in women who entered menopause after surgery. 90 women took either paroxetine or a placebo daily for 6 months. The goal was to see if paroxetine could be a safer alternative to …
Phase: PHASE2 • Sponsor: Universidad Nacional Autonoma de Honduras • Aim: Symptom relief
Last updated Jun 26, 2026 18:20 UTC
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Hormone therapy may boost sex life in early menopause, study hopes
Knowledge-focused CompletedThis study follows 135 women with premature ovarian failure (early menopause) to see if hormone replacement therapy improves their sexual quality of life. Participants fill out questionnaires about sexual function and well-being before starting treatment and again 6 months later.…
Phase: NA • Sponsor: University Hospital, Bordeaux • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Researchers measure breathing, strength, and quality of life in hospitalized endocrine patients
Knowledge-focused CompletedThis completed observational study at Uşak University examined 150 adults hospitalized in the endocrinology department. Researchers measured breathing, muscle strength, pain, fatigue, sleep quality, physical activity, balance, and nerve function. The goal was to better understand…
Sponsor: Uşak University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC