Could an antidepressant tame hot flashes without hormones?
NCT ID NCT06763484
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study tested whether paroxetine, a common antidepressant, can reduce hot flashes and night sweats in women who entered menopause after surgery. 90 women took either paroxetine or a placebo daily for 6 months. The goal was to see if paroxetine could be a safer alternative to hormone therapy, which carries risks like blood clots.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Paroxetine
- What this could lead to
- If it works, this could offer a non-hormonal option to ease hot flashes and night sweats for women who cannot take hormone therapy.
- What could go wrong
- This is a small, Phase 2 trial with only 90 participants. Paroxetine may cause side effects and might not work better than a placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Instituto Hondureño de Seguridad Social
Tegucigalpa, Francisco Morazán Department, 11101, Honduras
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