Cord blood plasma could repair thin uterine lining

NCT ID NCT05095597

Completed Disease control Sponsor: Fundación IVI Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested whether platelet-rich plasma from umbilical cord blood can thicken the endometrium (uterine lining) in women with Asherman's syndrome or endometrial atrophy. Fifteen women received an injection of the plasma into the uterine wall during a hysteroscopy, along with estrogen therapy. The goal was to see if the lining would grow enough to allow for embryo transfer in fertility treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: platelet-rich plasma from umbilical cord blood
What this could lead to: If successful, this could offer a new treatment to improve endometrial thickness in women with thin endometrium, potentially helping them become eligible for embryo transfer.
What could go wrong: This is a small, early-phase trial with only 15 participants, so results may not apply to everyone. The treatment is still experimental, and its safety and effectiveness are not yet proven.

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Conditions

The condition(s) this trial relates to.

Asherman syndrome gynatresia premature menopause

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ASHERMAN SYNDROME ENDOMETRIAL ATROPHY

Contacts and locations

Locations

Hospital la Fe

Valencia, Valencia, 46026, Spain

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