Postpoliomyelitis syndrome
MONDO:0017416Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis, 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.
Also known as: Post Polio Syndrome, postpolio sequelae, postpolio syndrome, postpoliomyelitic syndrome, postpoliomyelitis sequelae, postpoliomyelitis syndrome, polio late effects, post polio syndrome
26 clinical trials for this condition and its sub-types.
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Polio Survivors' hope dashed: trial of immune treatment halted early
Disease control Stopped earlyThis study tested a blood product called immune globulin (Flebogamma) in 191 people with post-polio syndrome, a condition causing new muscle weakness years after polio. The goal was to see if it could improve walking distance and reduce pain. The trial was terminated early, so we…
Phase 2/3 • Sponsor: Instituto Grifols, S.A. • Aim: Disease control
Last updated Jun 27, 2026 08:02 UTC
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Could emotional awareness therapy soothe mysterious body aches?
Symptom relief Stopped earlyThis pilot study tests whether a short-term group therapy called Emotional Awareness and Expression Therapy (EAET) can help people with persistent physical symptoms like pain or fatigue that have no clear medical cause. The therapy focuses on helping participants identify and exp…
Sponsor: Daniel Maroti • Aim: Symptom relief
Last updated Jul 29, 2026 00:00 UTC