Postpoliomyelitis syndrome
MONDO:0017416Postpoliomyelitis syndrome (PPS) is a neurologic disorder characterized by the development of new neuromuscular symptoms such as progressive muscular weakness or abnormal muscle fatigability occurring in survivors of the acute paralytic form of poliomyelitis, 15-40 years after recovery from the disease, and that is unexplained by other medical causes. Other manifestations that can occur gradually include generalized fatigue, muscle atrophy, muscle and joint pain, intolerance to cold, and difficulties sleeping, swallowing or breathing.
Also known as: Post Polio Syndrome, postpolio sequelae, postpolio syndrome, postpoliomyelitic syndrome, postpoliomyelitis sequelae, postpoliomyelitis syndrome, polio late effects, post polio syndrome
26 clinical trials for this condition and its sub-types.
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New clinic aims to break the cycle of useless tests for fatigue sufferers
Symptom relief OngoingThis study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…
Sponsor: Turku University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Can a stimulated muscle biopsy untangle two similar nerve and muscle diseases?
Knowledge-focused OngoingResearchers are testing a muscle biopsy method that uses mild electrical stimulation to sample the junction where nerves meet muscle. The goal is to see if this technique helps distinguish between inclusion body myositis and motor neuron disease, which can look alike. The study i…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Sep 03, 2026 00:00 UTC
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Sniffing out Parkinson's: new study uses nose, blood, and urine to catch disease early
Knowledge-focused OngoingThis study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Scientists compare immune responses to viral and bacterial infections in ICU patients
Knowledge-focused OngoingThis study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…
Sponsor: University Hospital, Limoges • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Massive review of viral meningitis cases aims to sharpen diagnosis
Knowledge-focused OngoingThis study looks back at 4000 patients who had a suspected viral infection of the brain or spinal cord. Researchers will analyze which viruses were found and how the illness progressed in different groups, including children, adults, and people with weakened immune systems. The g…
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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Smart sleeve study aims to improve movement for nerve disease patients
Knowledge-focused By invitation onlyThis study follows 1000 people with upper motor neuron disease who are about to receive the Cionic Neural Sleeve. The sleeve uses electrical stimulation to help muscles contract at the right time during movement. Researchers will track changes in health-related quality of life us…
Sponsor: Cionic, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC