Cure My Disease

Don't miss your cure!

 Log in / Sign up

Can a stimulated muscle biopsy untangle two similar nerve and muscle diseases?

NCT ID NCT07796776

Knowledge-focused Sponsor: IRCCS San Raffaele Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 01, 2026 · Last updated Sep 02, 2026 · Updated 1 time

Summary

Researchers are testing a muscle biopsy method that uses mild electrical stimulation to sample the junction where nerves meet muscle. The goal is to see if this technique helps distinguish between inclusion body myositis and motor neuron disease, which can look alike. The study involves 30 people with muscle weakness who need a biopsy for diagnosis. Researchers will compare tissue patterns, including a protein called TDP-43, to improve diagnostic accuracy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Muscle biopsy with electrostimulation for enhanced neuromuscular junction sampling
What this could lead to
If successful, this approach could sharpen the diagnosis between inclusion body myositis and motor neuron disease, leading to more accurate and earlier treatment decisions.
What could go wrong
This is a small, early diagnostic study with 30 participants, so the technique may not prove reliable in broader populations. The biopsy procedure carries standard risks like bleeding or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

30 adult patients with a neuromuscular disorder (suspected IBM or in differential diagnosis between IBM and MND)

Ages

18 years and older

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients exhibiting progressive muscle weakness and atrophy with a classic clinical IBM pattern or with an atypical clinical IBM pattern or with an atypical MND pattern * Able to understand and sign the informed consent * Treated according to standard of care clinical practice Exclusion Criteria: * Contraindications to needle EMG or skeletal muscle biopsy * Psychiatric diseases that may interfere with adherence to the follow-up protocol

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Inclusion body myositis (IBM) are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

amyotrophic lateral sclerosis inclusion body myositis motor neuron disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Inclusion body myositis (IBM) Motor neuron disease, amyotrophic lateral sclerosis

Contacts and locations

Locations

  • IRCCS Ospedale San Raffaele

    Milan, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.