Post-transplant lymphoproliferative disease
MONDO:0019088Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft. PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001)
Also known as: PTLD, post-transplant lymphoproliferative disorder
28 clinical trials for this condition and its sub-types.
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New combo therapy shows promise for kids with Transplant-Related cancer
Disease control CompletedThis pilot study tested a combination of rituximab (a targeted antibody) and specially trained immune cells (LMP-specific T-cells) in 18 children who developed a type of lymphoma after receiving a solid organ transplant. The goal was to see if this approach could effectively trea…
Phase: PHASE2 • Sponsor: Children's Oncology Group • Aim: Disease control
Last updated Jun 27, 2026 08:14 UTC
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Immune cell therapy shows promise for Post-Transplant cancer
Disease control CompletedThis study tested whether specially treated donor white blood cells could help treat a type of lymph cancer that sometimes occurs after an organ transplant. The cancer is linked to the Epstein-Barr virus. Fifty transplant recipients took part. The goal was to see if adding these …
Phase: PHASE3 • Sponsor: University of Edinburgh • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Could a smarter chemo schedule help kids beat cancer?
Disease control CompletedThis early-phase trial tested a chemotherapy regimen called DA-EPOCH-R in 4 children with certain B-cell cancers (DLBCL, PMBCL, or PTLD). The drugs are given as a continuous infusion over several days, and doses are adjusted based on how the child's body handles them. The goal wa…
Phase: EARLY_PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 07:54 UTC
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Lung transplant infection study aims to improve Long-Term survival
Knowledge-focused CompletedThis study followed 600 lung transplant recipients at the University of Pittsburgh to see how common viral and bacterial infections are and how they affect long-term health. Researchers focused on whether a specific infection (C. pneumoniae) is linked to a condition called bronch…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Virus tracking in kidney transplants may spot hidden risks
Knowledge-focused CompletedThis study followed 509 kidney transplant recipients to see if regularly measuring Epstein-Barr virus (EBV) levels in blood could predict serious infections, a type of cancer called PTLD, or death. Researchers compared virus levels in whole blood versus plasma to find the best wa…
Sponsor: University of Aarhus • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:58 UTC