Immune cell therapy shows promise for Post-Transplant cancer

NCT ID NCT00033475

Completed Disease control Sponsor: University of Edinburgh Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether specially treated donor white blood cells could help treat a type of lymph cancer that sometimes occurs after an organ transplant. The cancer is linked to the Epstein-Barr virus. Fifty transplant recipients took part. The goal was to see if adding these donor cells to standard care (reducing immune-suppressing drugs) led to better tumor shrinkage and survival.

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Conditions

The condition(s) this trial relates to.

lymphoproliferative syndrome post-transplant lymphoproliferative disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LYMPHOPROLIFERATIVE DISORDER

Contacts and locations

Locations

Birmingham Children's Hospital

Birmingham, England, B4 6NH, United Kingdom
Central Manchester and Manchester Children's University Hospitals NHS Trust

Manchester, England, M27 4HA, United Kingdom
Institute of Cancer Research - UK

Sutton, England, SM2 5NG, United Kingdom
King's College Hospital

London, England, SE5 8RX, United Kingdom
Northern General Hospital

Sheffield, England, S5 7AU, United Kingdom
Papworth Hospital

Cambridge, England, CB3 8RE, United Kingdom
Royal Free and University College Medical School

London, England, NW3 2PF, United Kingdom
Royal Infirmary - Castle

Glasgow, Scotland, G4 0SF, United Kingdom
Royal Infirmary of Edinburgh at Little France

Edinburgh, Scotland, EH16 4SA, United Kingdom
University of Edinburgh

Edinburgh, Scotland, EH8 1QH, United Kingdom
University of Edinburgh Laboratory for Clinical and Molecular Virology

Edinburgh, Scotland, EH9 1QH, United Kingdom
Wythenshawe Hospital

Manchester, England, M23 9LJ, United Kingdom

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