Post-COVID-19 disorder

The RECLAIM trial is testing whether two inexpensive, widely available drugs—metformin (a diabetes medication) and colchicine (a gout medication)—can improve quality of life for people with long COVID. The study will enroll 1,250 adults in the Netherlands who have had persistent …

This study tests whether a single dose of the monoclonal antibody AER002 can safely improve physical health in adults with Long COVID. The idea is that lingering virus or spike protein may cause ongoing symptoms, and the antibody might clear it. 36 participants will receive eithe…

This study tested an experimental stem cell treatment (HB-adMSCs) added to standard care for people aged 18-65 with Post-COVID-19 syndrome. Participants had not fully recovered weeks or months after a positive COVID-19 test. The goal was to see if the treatment is safe and helps …

This phase 3 trial tests whether taking Paxlovid (nirmatrelvir/ritonavir) during acute COVID-19 can prevent long COVID. About 2,000 adults aged 18-64 with a recent positive test and symptoms will receive either Paxlovid or a placebo for 5 days. Researchers will track long COVID s…

Researchers are testing whether a non-invasive device that stimulates the vagus nerve through the ear can help people with Long COVID recover after exertion. The trial enrolls 120 people with persistent symptoms such as fatigue, brain fog, and shortness of breath. Participants us…

This study is testing whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can improve symptoms like fatigue and brain fog in people with post-COVID syndrome. About 40 adults with long COVID will receive the treatment. The main goal is to see if a la…

This study tests whether a structured cognitive training program, called Goal Management Training, can improve attention and executive function in adults who have persistent cognitive difficulties after a COVID-19 infection. Participants aged 18 to 65 with confirmed COVID-19 and …

This study investigates whether a 16-week individually tailored exercise program, guided by a physiotherapist, can help adults with post-COVID POTS (postural orthostatic tachycardia syndrome) spend more time upright and feel better. Participants are randomly assigned to either th…

This Phase 2 trial tests whether the drug plitidepsin can improve overall health in 90 adults with moderate-to-severe long COVID symptoms. Participants receive either plitidepsin or a placebo intravenously over four 3-day cycles, with a 90-day follow-up. The study is double-blind…

This study tests a type of talking therapy called Balance ACT for people with long COVID. The therapy uses mindfulness and goal-setting to help manage symptoms like fatigue and sleep problems. 196 adults with long COVID will either get the therapy or a self-help leaflet. The main…

This trial tests whether training general practitioners to better manage persistent symptoms after COVID-19 can improve patients' quality of life. Adults with at least two long COVID symptoms (like fatigue, breathlessness, or brain fog) lasting over two months will be enrolled. T…

This study tests a personalized health pathway for 400 people with persistent COVID-19 symptoms lasting more than 12 weeks. Participants receive nurse follow-up and can choose workshops on disease management, anxiety, and fatigue. The goal is to see if this approach improves qual…

This study compares a 12-week tele-rehabilitation program using mindful and conscious movement (like adapted yoga and breathing exercises) to conventional low-intensity exercise and usual care for people with chronic fatigue syndrome or post-COVID syndrome. The goal is to see if …

This phase 2a trial tests whether the drug abrocitinib can reduce severe fatigue in adults with Long COVID. About 46 people who were never hospitalized for COVID but now have long-term fatigue will take either 50 mg, 100 mg of abrocitinib, or a placebo daily for 12 weeks. Researc…

This study tests whether the drug vericiguat, already approved for heart failure, can improve physical function and reduce fatigue in people aged 18-50 with post-COVID syndrome. About 104 participants will receive either vericiguat or a placebo for 10 weeks, then be followed for …

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study collects and analyzes blood, DNA, and tissue samples from 315 adults with pulmonary fibrosis, their relatives, and healthy volunteers. The goal is to learn more about the disease's causes, not to test a new treatment. Researchers hope the findings will guide future the…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will compare 150 adults with and without…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This study looks at what happens in the body to cause POTS and dysautonomia after viral infections, including COVID-19. About 100 women will give a blood sample and share medical records. Researchers will study immune system markers to find clues that could lead to better diagnos…

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This small pilot study looks at how the gut microbiome might be linked to lingering symptoms after severe COVID-19. Researchers will measure changes in gut bacteria, immune markers, and lung function in 20 adults who had severe COVID in the past year. The goal is to find better w…

This study looks at whether problems with blood vessels in the lungs cause ongoing shortness of breath in people who had COVID-19. Researchers will use heart and lung tests, including exercise and imaging, in 200 adults. The goal is to better understand why some people feel breat…