Can metformin or colchicine ease long COVID? major trial launches
NCT ID NCT07280572
First seen Jan 05, 2026 · Last updated Jun 20, 2026 · Updated 27 times
Summary
This Phase 3 trial is testing whether two widely available drugs—metformin and colchicine—can improve physical health and reduce symptoms like fatigue in people with long COVID. About 1,250 adults in the Netherlands will take one of the drugs or receive usual care for 12 weeks, with all participation done remotely via video calls and home delivery. The goal is to find safe, practical treatments for the millions struggling with persistent post-COVID symptoms.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Julius Center for Health Sciences and Primary Care University Medical Center Utrecht, Netherlands
Utrecht, Netherlands
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin and colchicine
What this could lead to
If successful, this could point toward simple, repurposed drugs to improve quality of life for people with long COVID.
What could go wrong
This is an early-stage platform trial, and the drugs may not prove effective for long COVID. Side effects from metformin or colchicine are possible.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.