Penile cancer

This study tests a new combination of two drugs (becotatug vedotin and pucotenlimab) in 20 adults with advanced penile cancer that has spread and is EGFR-positive. Participants must have failed or be unable to tolerate chemotherapy. The goal is to see if the treatment can shrink …

This phase II trial tests a combination of two drugs—Becotatug vedotin (a targeted therapy that attacks cancer cells with a specific protein) and Pucotenlimab (an immunotherapy that boosts the immune system)—in men with advanced penile cancer that is hard to treat with surgery al…

This study investigates penile transplantation as a way to replace a severely damaged or missing penis with a donor organ, aiming to restore appearance, sensation, and sexual function. It includes men aged 18-69 who have lost their penis due to trauma, surgery, or birth defects. …

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study tests a drug called enfortumab vedotin for people with penile cancer that has spread or cannot be removed by surgery. The drug works like a smart bomb, targeting a protein on cancer cells to deliver a toxin that kills them. About 28 adults will take part to see if the …

This study tests two drugs, QL1706 and lenvatinib, in people with advanced penile cancer that has already been treated. The goal is to shrink tumors and possibly make them removable by surgery. About 47 adults aged 18–80 will receive the drugs for up to a year, with the aim of co…

This study tests whether robot-assisted groin lymph node removal causes fewer serious side effects than standard open surgery in 80 men with penile cancer. The goal is to reduce wound healing problems and other complications while still effectively controlling the cancer. Partici…

This early-phase trial tests a new two-drug combination (MRG003 and HX008) as a first treatment for advanced penile cancer that has spread. It aims to be more effective and less toxic than standard chemotherapy. The study enrolls 10 men with a specific type of cancer (EGFR-positi…

This phase 2 trial tests whether giving pembrolizumab (Keytruda) plus chemotherapy (carboplatin and paclitaxel) before surgery can completely eliminate advanced penile cancer in the penis and lymph nodes. About 27 men with resectable, node-positive penile cancer will receive the …

This study tests two experimental drugs, SI-B003 alone or combined with BL-B01D1, in people with advanced bladder cancer or other solid tumors that have not responded to standard treatments. The goal is to see if these drugs can shrink tumors or slow disease progression. About 52…

This study collects blood, urine, saliva, and tissue samples from nearly 6,000 people who have or may have cancer, including rare inherited forms. The samples are stored and used for research to understand the genetic and molecular basis of cancer. No new treatment is being teste…

This study follows 1,100 adults with rare urinary tract cancers, such as unusual bladder, kidney, testicular, or penile cancers. Researchers will collect medical records, blood and tumor samples, and imaging over many years to understand how these cancers grow and respond to trea…

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study follows 400 patients who have had urologic cancer surgery with lymph node removal to see how often they develop lymphedema (leg swelling). Researchers will use questionnaires and special devices to measure swelling and tissue fluid over two years. The goal is to better…