Paramyxoviridae infectious disease

This study tests a new vaccine that protects against measles, mumps, rubella, and chickenpox (MMRV) in healthy children aged 15 months to 6 years. It compares the new vaccine to an already approved one (ProQuad) to see if it works as well and is safe. About 1,200 children will re…

This study tests an experimental drug called DAS181 in people with weakened immune systems who have a serious lung infection caused by parainfluenza virus. The goal is to see if the drug helps them breathe without extra oxygen and reduces the risk of death. About 274 participants…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests an inhaled medicine called SNG001 in patients with severe viral pneumonia who need a breathing machine. The goal is to see if it safely helps clear the virus faster and lowers the risk of death. About 550 adults, mostly over 50 or with weakened immune systems, wi…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study looks at whether the measles, mumps, and rubella (MMR) vaccine is safe and works well in children aged 1 to 17 who have had a heart transplant. About 60 children will receive the standard MMR vaccine and be monitored for side effects and immune response. The goal is to…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study collects blood and nasal secretions from up to 2,000 people with COVID-19 to learn why some get very sick while others recover easily. Researchers will also track long-term symptoms like fatigue and brain fog. No treatments are tested—the goal is to gather data to guid…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study investigates the 'measles paradox'—how measles can temporarily weaken the immune system while also providing lifelong protection. Researchers will track immune memory cells in 300 adults before and after measles infection. The goal is to understand how measles causes i…