Optic nerve disorder

This study tests an experimental gene therapy called ASP2767 in people with open-angle glaucoma, a common eye disease that damages the optic nerve and can lead to vision loss. The therapy uses a harmless virus to deliver genes into the eye, helping retinal nerve cells produce pro…

This study tests a nasal spray called cenegermin to see if it can improve vision in people who recently lost eyesight from a condition called NAION (a stroke in the optic nerve). About 272 adults will receive either the spray or a placebo. The goal is to measure if more people ga…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This study tests whether injecting a person's own bone marrow stem cells into or near the eye can help treat various retinal and optic nerve diseases, including age-related macular degeneration, retinitis pigmentosa, and glaucoma. Participants receive stem cell injections via dif…

This early-stage trial is testing a brain implant designed to create artificial vision in people who are blind. Five participants will have a wireless device surgically placed in the part of the brain that processes vision. The study will check if the device is safe and whether i…

This early-stage trial is testing a single dose of ER-100, a gene therapy designed to reverse age-related changes in retinal cells, in 18 adults with open-angle glaucoma or NAION. Participants receive the therapy via an eye injection and take doxycycline for 8 weeks to activate i…

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study tests a special camera that takes detailed images of the retina using many wavelengths of light. Researchers hope it can find early signs of eye diseases like age-related macular degeneration, diabetic retinopathy, and glaucoma. About 1,000 adults in Melbourne, Austral…

This pilot study tests a new handheld OCT device that automatically aligns to the eye to take detailed pictures of the retina. Researchers will scan 50 healthy adults, adult patients, and children in eye clinics to see if the device works well. The goal is to make retinal imaging…

This study tests if a gentle electrical stimulation device, used at home every other day for 8 weeks, can slow vision loss and improve daily function in people with optic neuropathy. Researchers will measure changes in eye structure, visual field, and quality of life in 70 adults…

This study is testing a new non-invasive device that uses laser speckle to measure blood flow and structure inside the eye. Researchers will compare these images with standard vision tests in 500 people with various retinal conditions. The goal is to see if this technology can be…

This study tests a new handheld eye scanner (Theia 1) against an existing one to see which takes better pictures of children's retinas. Researchers will scan 30 healthy adults and children to compare image quality and field of view. The goal is to improve diagnosis of eye disease…

This study aims to create a database of eye images using a new holographic Doppler laser device. The goal is to better visualize and measure blood flow in the retina and choroid, which is important for diagnosing eye diseases. About 123 adults, both with and without eye condition…