Nasal spray could reverse sudden blindness in groundbreaking trial

NCT ID NCT07453888

Recruiting now Disease control Sponsor: Dompé Farmaceutici S.p.A Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 16, 2026 · Updated 2 times

Summary

This study tests a nasal spray called cenegermin to see if it can improve vision in people who recently lost eyesight from a condition called NAION (a stroke in the optic nerve). About 272 adults will receive either the spray or a placebo. The goal is to measure if more people gain at least 15 letters on an eye chart after treatment.

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Conditions

The condition(s) this trial relates to.

anterior ischemic optic neuropathy non-arteritic anterior ischemic optic neuropathy optic nerve disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ARTERITIC ANTERIOR ISCHEMIC OPTIC NEUROPATHY

Contacts and locations

Locations

Bascom Palmer Eye Institute, University of Miami School of Medicine
NOT_YET_RECRUITING

Miami, Florida, 33136, United States
California Orbital Consultants
NOT_YET_RECRUITING

Newport Beach, California, 92660, United States
David Geffen School of Medicine at UCLA - Ophthalmology
NOT_YET_RECRUITING

Los Angeles, California, 90095, United States
Mayo Clinic - Department of Ophthalmology
RECRUITING

Rochester, Minnesota, 55905, United States
Neuro Eye Clinical Trials
RECRUITING

Houston, Texas, 77074, United States
Neuro Eye Orbit Institute
RECRUITING

Los Angeles, California, 90048, United States
Northwestern University - Ophthalmology
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Retina Consultants of South Carolina, Charleston Neuroscience Institute- West Ashley (RCA)
RECRUITING

Charleston, South Carolina, 29414, United States
Sarasota Retina Institute - Research
NOT_YET_RECRUITING

Sarasota, Florida, 34239, United States
The Johns Hopkins Hospital (JHH)
NOT_YET_RECRUITING

Baltimore, Maryland, 21287, United States
Trinity Health Grand Rapids
NOT_YET_RECRUITING

Grand Rapids, Michigan, 49503, United States
Tufts Medical Center - Neurology
NOT_YET_RECRUITING

Boston, Massachusetts, 02116, United States
Univ. Of Kentucky Clinic Dept of Ophthalmology & Vision Science
NOT_YET_RECRUITING

Lexington, Kentucky, 40508, United States
University of Colorado Anschutz Medical Campus
RECRUITING

Aurora, Colorado, 80045, United States
University of Illinois at Chicago Eye and Ear Infirmary - Ophthalmology
NOT_YET_RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan Health - Kellogg Eye Center
RECRUITING

Ann Arbor, Michigan, 48105, United States
University of Minnesota, Dept of Ophthalmology
NOT_YET_RECRUITING

Minneapolis, Minnesota, 55455, United States
University of Pennsylvania - Ophthalmology
RECRUITING

Philadelphia, Pennsylvania, 19104, United States