Onchocerciasis
MONDO:0017137Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy.
Also known as: Onchocerca volvulus infection, infection by Onchocerca volvulus, onchocerciasis, River blindness, Robles' disease, infection caused by Onchocerca volvulus, onchocercosis
10 clinical trials for this condition and its sub-types.
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Broader categories
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NIH opens study to treat parasitic infections like malaria and worms
Disease control Recruiting nowThis study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Jul 30, 2026 00:00 UTC
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Can mapping migrant networks help end neglected tropical diseases?
Disease control Recruiting nowThis study tests a community-designed strategy to deliver preventive chemotherapy to mobile and migrant populations in Nigeria, who often miss treatment for neglected tropical diseases like river blindness and schistosomiasis. Researchers will work with communities to map migrati…
Phase: NA • Sponsor: Uwemedimo Friday Ekpo • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Massive drug showdown: can a new pill beat river blindness for good?
Disease control Recruiting nowThis study compares two drugs, ivermectin and moxidectin, to see which works better at controlling river blindness and other common infections like intestinal worms and scabies in Angola. Over 52,000 people in 20 village groups will receive one of the drugs once a year for four y…
Phase: PHASE4 • Sponsor: Kirby Institute • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Scientists seek clues to why some get sick from parasitic worms
Knowledge-focused Recruiting nowThis study looks at how people's immune systems react to infections from parasitic worms, which can cause serious health problems like swelling, blindness, or heart disease. Researchers will evaluate and treat up to 500 participants aged 3 to 100 using standard medical tests and …
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 18, 2026 05:00 UTC