Onchocerciasis
MONDO:0017137Onchocerciasis is a form of filariasis, caused by the parasitic worm Onchocerca volvulus, transmitted by the black fly. The infection can either be asymptomatic or manifest as an ocular disease (river blindness) with itchy eyes, erythema, photophobia, onchodermatitis or onchocercal skin disease (classified into acute papular, chronic papular, lichenified, atrophic, and depigmentated) and onchocercomas (over bony prominences). Other classic clinical manifestations are ichthyosis-like lesions (''lizard skin'') and ''hanging groin'', which may be associated with lymphadenopathy.
Also known as: Onchocerca volvulus infection, infection by Onchocerca volvulus, onchocerciasis, River blindness, Robles' disease, infection caused by Onchocerca volvulus, onchocercosis
10 clinical trials for this condition and its sub-types.
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New drug moxidectin put to the test against river blindness in massive safety trial
Disease control CompletedThis large Phase 3 trial compared the safety of a single dose of moxidectin versus ivermectin in nearly 13,000 people living in areas where river blindness is common. Some participants also received albendazole for lymphatic filariasis. The goal was to see if moxidectin causes fe…
Phase: PHASE3 • Sponsor: Medicines Development for Global Health • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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River blindness drug trial aims to find right dose for kids
Disease control CompletedThis study tested a single dose of moxidectin in 36 children aged 4 to 17 who have or are at risk of onchocerciasis (river blindness). The goal was to find a dose for children 4-11 years that works like the standard 8 mg dose used in older kids and adults. Researchers measured dr…
Phase: PHASE1 • Sponsor: Medicines Development for Global Health • Aim: Disease control
Last updated Jun 26, 2026 13:56 UTC