Obstructive lung disease

This trial investigates whether custom-made stents, designed using 3D computer modeling and printing, can safely treat complex airway narrowing that standard stents cannot fit. Ten adults with symptomatic, anatomically complex airway stenosis will receive a personalized stent and…

This study tested whether video-based medication coaching helps adolescents and young adults with uncontrolled asthma take their inhaled steroids more regularly. 375 participants received either standard care or telehealth sessions to improve medication use. The goal was to see i…

This study tested a new way to give Alpha-1 protein therapy by injecting it under the skin instead of into a vein. Seventeen adults with Alpha-1 Antitrypsin Deficiency received either a low or high dose weekly for eight weeks. The main goal was to check safety and how the drug mo…

This study tested whether the drug vapendavir can reduce breathing problems in people with COPD who catch a rhinovirus (common cold). Fifty-two adults with COPD were given either vapendavir or a placebo after being exposed to the virus. The main goal was to see if vapendavir lowe…

This study investigates whether patterns in speech and breathing can indicate the presence of obstructive respiratory diseases like COPD. Researchers will collect short voice recordings from patients with and without lung disease and compare them to standard lung function tests. …

This study tested a single dose of a new albuterol inhaler called PT007 in 118 adults with asthma. Researchers compared how well it opened airways and its safety against a placebo inhaler and the standard Ventolin inhaler. The goal is to see if PT007 works as a quick-relief treat…

This study tested a new ventilator mode called NAVA for people with chronic obstructive pulmonary disease (COPD) who need a breathing machine. NAVA uses the patient's own diaphragm signals to control the machine, aiming to improve comfort and reduce time on the ventilator. The st…

This study tested two different spacer devices (valved holding chambers) used to give asthma medicine to children aged 6 months to 4 years with sudden wheezing. 80 children from Finnish hospitals took part. The goal was to see if one spacer worked better for symptom relief, hospi…

This study looked at whether people with chronic lung disease who experience drops in oxygen during exercise can walk just as far without extra oxygen as with it. Forty patients completed a 6-minute walk test twice: once breathing normal air and once with low-flow oxygen. The goa…

This study looks at how children born preterm with chronic lung disease respond to different inhaled bronchodilators. Participants will have their lung function tested before and after using three types of inhalers: salbutamol, ipratropium bromide, and a combination of fenoterol …

This study tested a special MRI technique called Ultra Short Echo Time (UTE) to see if it can take clearer pictures of the lungs than traditional MRI. Researchers collected images and health information from people with and without lung disease to help doctors better understand l…

This study tested a clinical decision support tool called PREVENT to help nurses prioritize which patients need homecare most urgently after leaving the hospital. Researchers studied nearly 2,000 adults with conditions like diabetes, heart failure, and lung disease to see if the …