Nervous system injury

Researchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…

This study tests whether a single IV infusion of stem cells taken from a patient's own belly fat can safely improve brain structure and thinking skills after a traumatic brain injury. The trial enrolls 51 adults aged 18-55 who have had a brain injury for at least 6 months but no …

This study tests a behavioral training program that teaches people with chronic spinal cord injury to reduce a specific leg reflex. The goal is to decrease spasticity and improve walking speed and distance. 25 participants will train for about 6 months, with researchers measuring…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation…

This study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …

This study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…

This study follows 100 adults who had surgery for traumatic nerve injuries in the hand or arm. Researchers will measure hand function, strength, and quality of life over time to better understand long-term recovery. The goal is to gather information, not to test a new treatment.

This study tests whether a simple procedure called remote ischemic preconditioning (RIPC) — briefly restricting blood flow to an arm or leg — can reduce brain injury after non-cardiac surgery. The trial will include 216 older adults at risk for postoperative delirium. Researchers…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …