Nephrogenic diabetes insipidus

This early-stage trial tests a daily capsule called NDI-5001 in 24 adult men with a rare inherited kidney condition (X-linked congenital nephrogenic diabetes insipidus) that causes extreme thirst and frequent urination. The study's main goal is to check the drug's safety and how …

This study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…

This early-stage study is testing a single dose of the drug MK-2828 in 24 people with different levels of kidney function, including those with severe kidney failure or on dialysis. The goal is to measure how the drug moves through the body over time and compare it to healthy vol…

This early-stage study looks at how a single dose of VC005 tablets is processed in people with kidney impairment compared to those with normal kidney function. Researchers will measure drug levels in the blood and check safety. The goal is to understand if kidney problems affect …

This study looks at how the medicine PF-07328948 moves through the body in adults with different levels of kidney function. About 28 people aged 18 to 80, with either normal kidneys or moderate-to-severe kidney problems, will take a single tablet. Researchers will check safety an…

This study will enroll 5,000 adults with kidney disease or at risk for it, including transplant recipients. Researchers will analyze blood and urine samples to find molecular patterns that predict disease progression, complications, or treatment response. The goal is to improve r…

This early-stage study tests how a single dose of the diabetes drug GL0034 behaves in people with different levels of kidney function. About 40 adults with type 2 diabetes will be grouped by kidney health, from normal to severe impairment. Researchers will measure drug levels in …

This study is for adults who have had a liver transplant and now have kidney issues. Researchers want to learn how often kidney function gets worse and what factors might cause that decline. They will look at results from kidney biopsies already done in the past 3 months. The goa…

This early-stage study tests a single dose of the drug GZR18 in 32 adults who are overweight or obese, some with mild to severe kidney problems and some with normal kidneys. Researchers want to see how kidney function affects drug levels and safety. The goal is to find the right …

This study follows 100 women who had preeclampsia, HELLP syndrome, or kidney problems during pregnancy. Researchers will measure blood vessel stiffness and collect blood samples for a biobank. The goal is to better understand long-term heart and kidney health after these conditio…