Nephrogenic diabetes insipidus

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested a new wearable patch that collects sweat to measure sodium and creatinine levels, which are important for monitoring kidney health and dehydration. Five adults with kidney disease wore the patch while their sweat was analyzed using a special light-based techniqu…

This study tested whether the medication PB can safely reduce excessive urination in people with certain kidney diseases, including inherited nephrogenic diabetes insipidus, lithium-induced diabetes insipidus, and polycystic kidney disease treated with tolvaptan. Researchers meas…

This study looked at how the drug LY3502970 behaves in people with healthy kidneys compared to those with kidney problems. Researchers measured how much drug gets into the blood and how fast the body clears it. The goal is to understand if kidney impairment changes drug levels, w…

This study looked at how the drug MCI-186 is handled by the body in people with mild or moderate kidney impairment compared to those with normal kidneys. Thirty adults received a single dose of the drug, and researchers measured its levels in the blood. The goal was to understand…

This study looked at how the drug LY3537031 moves through the body in people with different levels of kidney function. It included 31 adults with normal kidneys, kidney impairment, or end-stage kidney disease. The goal was to measure drug levels in the blood and how long it takes…

This study looked at how a single dose of the drug EDG-7500 stays in the blood of people with various levels of kidney function, from normal to severely impaired. It involved 37 adults aged 18-75. The goal was to understand if kidney problems change drug levels, which helps docto…

This study looks at how a single injection of BI 456906, a drug being developed for obesity and liver disease, behaves in the blood of people with different levels of kidney function. Researchers will compare drug levels in 42 adults with normal kidneys to those with mild, modera…

This study looked at how a single dose of the drug AMG 133 is processed by the body in people with normal kidney function compared to those with various levels of kidney problems. A total of 44 adults aged 18 to 75 who are overweight or obese took part. The goal was to understand…

This completed Phase 1 study looked at how the drug MK-8527 is processed in people with moderate or severe kidney impairment compared to healthy volunteers. Eighteen participants received a single oral dose, and researchers measured drug levels in the blood over time. The goal wa…

This study looks at how the drug calderasib (MK-1084) behaves in people with moderate or severe kidney problems compared to healthy volunteers. Researchers will measure drug levels in the blood after a single dose to see if kidney function changes how the body processes it. The s…

This study tested a new weight-management drug called petrelintide in 39 people with normal or impaired kidney function. Researchers wanted to see if kidney problems change how the drug behaves in the body. The goal is to guide safe dosing for people with kidney issues who might …

This study followed nearly 6,000 people with kidney disease from around the world. Researchers collected routine test results like kidney function and protein in urine to better understand how the disease progresses. The goal was to gather information, not to test a new treatment…

This completed Phase 1 study looked at how the drug AZD5462 behaves in people with reduced kidney function compared to healthy volunteers. Sixteen participants received a single oral dose, and researchers measured drug levels in the blood and monitored for side effects. The goal …

This study tested whether having a clinical pharmacist work alongside doctors in a hospital ward could reduce medication errors in patients with kidney disease. Researchers followed 160 adults with reduced kidney function, comparing usual care, doctor education, and active pharma…

This early-phase study looked at how a single dose of the drug olpasiran moves through the body in people with normal kidneys and those with various levels of kidney impairment. Thirty-three adults received one shot under the skin. The main goal was to measure drug levels in the …

This study looked at how the tuberculosis drug pretomanid is processed in people with different levels of kidney function. Twelve participants received a single 200 mg dose, and researchers compared drug levels in those with kidney impairment to healthy matched controls. The goal…

This study looked at how the experimental drug MBX 2109 is handled by the body in people with different levels of kidney function. 25 adults with normal or impaired kidneys received a single dose. The goal was to measure safety and drug levels, not to treat a disease. Results wil…

This study looked at how the body processes the drug selpercatinib (LOXO-292) in people with different levels of kidney function. Researchers gave a single dose to 37 volunteers—some with healthy kidneys and some with kidney impairment—and measured drug levels in the blood and ur…