Monkeypox

This study tested the JYNNEOS smallpox vaccine in 1,600 healthcare workers in the Democratic Republic of the Congo who are at high risk of catching mpox. The goal was to see if the vaccine can prevent mpox infection and is safe to use. Participants received the vaccine and were m…

This study tested whether giving a smaller dose of the MVA-BN (JYNNEOS) monkeypox vaccine under the skin works as well as the standard full dose given into the muscle. About 229 healthy adults aged 18 to 50 received either one-fifth or one-tenth of the standard dose under the ski…

This study tested the JYNNEOS mpox vaccine in 450 healthy teens and adults to see if it works as well in adolescents aged 12-17 as it does in adults. Participants received two shots under the skin. The main goal was to compare immune responses and check for side effects. Results …

This early-stage trial tested an RNA-based vaccine called BNT166a against mpox (monkeypox) in 96 healthy volunteers. The goal was to check safety and see if the vaccine triggers an immune response. Researchers looked for side effects like pain, fever, and fatigue, and monitored s…

This completed study monitored the safety of the MVA-BN (Jynneos) vaccine in 500 adults at high risk for monkeypox in the Democratic Republic of the Congo. Participants received two doses of the vaccine and were followed for up to 28 days after their last dose. The main goal was …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether the drug tecovirimat is safe and effective for treating monkeypox (mpox). About 600 adults and children with confirmed mpox and active skin lesions took either tecovirimat or a placebo for 14 days, along with standard care. The main goal was to see how q…

This completed trial tested the antiviral drug tecovirimat (TPOXX) in 328 adults and children with mpox. Participants received either tecovirimat or a placebo to see if the drug speeds up healing of skin lesions. The study also tracked safety and natural disease progression durin…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This completed study looked at 550 people with mpox to see how long the virus stays in the body and how it spreads to close contacts. Researchers measured viral levels in skin lesions, throat swabs, and blood over time. The goal is to provide better guidance on when it's safe to …

This study looked at 320 people with mpox to check for eye complications. Researchers performed standard eye exams to see what eye problems might occur. The goal was to better understand how often and in what ways mpox affects the eyes.

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …