Mitral valve stenosis

This study tests a new device called Tendyne, which is a replacement heart valve placed through a tube in the blood vessels, avoiding open-heart surgery. It is for people with a leaky mitral valve (mitral regurgitation) who are too high-risk for traditional surgery. The trial com…

This study tracks how well the MITRIS RESILIA mitral valve works in real-world patients who need a new mitral valve due to narrowing or leakage. About 504 adults having valve replacement surgery will be followed for safety and performance, including valve function and major heart…

This study tests whether a bedside device called Quantra can help doctors decide when to give blood transfusions during complex heart surgery. The device measures how well a patient's blood clots in real time. Researchers hope this will reduce the number of blood products (like r…

This study compares dabigatran (Pradaxa) to warfarin for preventing strokes in 370 people with both atrial fibrillation and moderate-to-severe mitral stenosis. Participants are randomly assigned to one of the two blood thinners. The goal is to see if dabigatran is as good as or b…

This study looks at whether doing a heart valve repair procedure early, before symptoms appear, is better than waiting and using standard care for people with moderate mitral stenosis. The trial includes 167 participants who have no symptoms but are at risk for future heart probl…

This study was designed to see if early mobilization and a simple bottle-based breathing device (Bottle-P.E.P.) could improve breathing and physical function in people recovering from heart valve surgery. The trial was withdrawn before enrolling any participants, so no results ar…

This study tests a new sensor worn on the skin that measures lactate levels without needles. It involves 20 adults recovering from heart bypass or valve surgery. The goal is to see if the sensor works as well as standard blood tests, which could make monitoring more comfortable a…

This study compares two methods for deciding which blocked heart arteries need bypass during valve surgery. The standard method uses angiography (X-ray dye), while the new method uses a computer calculation called QFR. About 792 patients will be randomly assigned to one method, a…

This study looks at 3500 people who had their mitral valve replaced to see if the original problem (narrowing, leaking, or both) affects how long the new valve lasts. Researchers will check echocardiograms and health records over time. The goal is to better understand why some re…