New heart valve tested in global study to improve valve replacement outcomes

NCT ID NCT05526560

Ongoing Disease control Sponsor: Edwards Lifesciences Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tracks how well the MITRIS RESILIA mitral valve works in real-world patients who need a new mitral valve due to narrowing or leakage. About 504 adults having valve replacement surgery will be followed for safety and performance, including valve function and major heart events. The goal is to confirm the valve's long-term benefits in everyday medical practice.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

mitral valve insufficiency mitral valve stenosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MITRAL STENOSIS MITRAL VALVE INSUFFICIENCY

Contacts and locations

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Locations

AdventHealth Orlando

Orlando, Florida, 32803, United States
Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212, United States
Ascension Saint Thomas

Nashville, Tennessee, 37205, United States
Ascension St. Vincent Heart Center

Carmel, Indiana, 46290, United States
Aurora St. Luke's Medical Center

Milwaukee, Wisconsin, 53215, United States
Cleveland Clinic London

London, SW1X 7HY, United Kingdom
Columbia University Irving Medical Center

New York, New York, 10032, United States
Deutsches Herzzentrum München

München, 80636, Germany
Duke University Medical Center

Durham, North Carolina, 27703, United States
Herz- und Diabeteszentrum NRW

Bad Oeynhausen, 32545, Germany
Hoag Memorial Hospital Presbyterian

Newport Beach, California, 92663, United States
Hospital of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval

Québec, QC G1V 4G5, Canada
King's College Hospital

London, SE5 9RS, United Kingdom
Klinikum Links der Weser

Bremen, 28277, Germany
London Health Sciences Centre, University Hospital (LHSC)

London, Ontario, N6G 5G1, Canada
Mayo Clinic, Rochester

Rochester, Minnesota, 55905, United States
Montreal Heart Institute

Montreal, Quebec, H1T 1C8, Canada
Mount Sinai Hospital

New York, New York, 10029, United States
Piedmont Heart Institute

Athens, Georgia, 30606, United States
Piedmont Heart Institute

Atlanta, Georgia, 30309, United States
Rhoen-Klinikum Campus Bad Neustadt

Bad Neustadt an der Saale, 97616, Germany
Royal Papworth Hospital

Cambridge, SE5 9RS, United Kingdom
St. Paul's Hospital and Vancouver General Hospital

Vancouver, British Columbia, V6Z 1Y6, Canada
St. Thomas Hospital

London, SE1 7EH, United Kingdom
Stanford University

Palo Alto, California, 94305, United States
Tristar Centennial Medical Center

Nashville, Tennessee, 37203, United States
UPMC Presbyterian Shadyside

Pittsburgh, Pennsylvania, 15232, United States
University Clinic Bonn

Bonn, 53127, Germany
University of Michigan

Ann Arbor, Michigan, 48109, United States
University of Utah

Salt Lake City, Utah, 84112, United States
Universitätsklinikum Augsburg

Augsburg, 86156, Germany
Washington University Barnes-Jewish Hospital

St Louis, Missouri, 63110, United States
Weill Cornell Medicine

New York, New York, 10065, United States