Mitral valve prolapse
MONDO:0004910A fairly common and often benign valvular heart disorder characterized by redundancy or hooding of mitral valve leaflets so that they prolapse into the left atrium, often causing mitral regurgitation. It is often a symptomless condition but may be marked by varied symptoms (e.g. chest pain, fatigue, dizziness, dyspnea, or palpitations) leading in some cases to endocarditis or ventricular tachycardia.
Also known as: barlow's syndrome, floppy mitral valve, mitral valve prolapse, mitral valve prolapse (disease), mitral valve prolapse syndrome, prolapse, mitral valve, valve, prolapse Of mitral, mitral valve prolapse, myxomatous
53 clinical trials for this condition and its sub-types.
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Broader categories
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New heart valve technology put to the test in 777 patients
Disease control CompletedThis study tested whether a new way of processing tissue for Edwards heart valves is safe and works well. 777 adults who needed a new aortic or mitral valve took part. Researchers checked for valve problems like wear or calcification over about a year, and will follow patients fo…
Phase: NA • Sponsor: Edwards Lifesciences • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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Nerve block before heart surgery may shield muscle from damage
Disease control CompletedThis study tested whether a left stellate ganglion block, given before mitral valve replacement, could protect the heart muscle. 62 adults undergoing elective on-pump mitral valve replacement received either a saline placebo or bupivacaine nerve block. Researchers checked for mic…
Phase: NA • Sponsor: Minia University • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Which workout helps heart surgery patients recover faster?
Symptom relief CompletedThis study looked at two types of exercise training—moderate-intensity interval training and continuous training—in 56 adults aged 40-60 who had mitral valve replacement surgery 4-8 weeks earlier. Over 12 weeks, researchers measured walking ability, lung function, heart efficienc…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:08 UTC
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Healing sounds and sights: VR and binaural beats tested for Post-Surgery sleep
Symptom relief CompletedThis study tested whether virtual reality relaxation or binaural beat stimulation can improve sleep and reduce discomfort in 140 adults who had mechanical heart valve replacement. Many patients struggle with sleep due to the sound of the new valve. Participants were randomly assi…
Phase: NA • Sponsor: University of Baghdad • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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Tiny valve may help tracheostomy patients walk further
Symptom relief CompletedThis study looked at whether using a Passy-Muir valve (a small device that helps people with a tracheostomy speak) can also improve how far they can walk. 26 adults with a tracheostomy completed several 6-minute walk tests, alternating between using the valve and leaving the trac…
Phase: NA • Sponsor: Gaylord Hospital, Inc • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Heart monitoring breakthrough: 14 days vs. 24 hours for MVP patients
Knowledge-focused CompletedThis study tests whether wearing a heart monitor for 14 days can detect dangerous heart rhythms in people with mitral valve prolapse (a common heart valve condition) better than the usual 24-hour test. About 60 adults with MVP will wear a patch monitor for two weeks. The goal is …
Phase: NA • Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jul 23, 2026 00:00 UTC
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Heart valve choice may impact your mental health years later
Knowledge-focused CompletedThis study looked at 1,811 patients aged 60-70 who had heart valve replacement surgery. Researchers compared different types of artificial valves to see if the valve type was linked to developing depression, anxiety, or sleep disorders later. The goal was to understand if the cho…
Sponsor: Samsung Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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AI spots hidden heart valve risks in routine scans
Knowledge-focused CompletedThis completed study used artificial intelligence to analyze electrocardiograms (ECGs) and chest X-rays from over 116,000 adults. The goal was to see if combining these routine tests could predict which patients would develop moderate or severe heart valve regurgitation. The rese…
Sponsor: Shanghai Zhongshan Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Heart surgery study seeks to pinpoint protection window
Knowledge-focused CompletedThis study looked at 80 adults having heart valve or aortic surgery to find out how long a special heart protection solution (Del Nido cardioplegia) keeps the heart safe during surgery. Researchers took blood samples at set times to see when heart injury began. The goal was to le…
Sponsor: Muhammet Talha Ceran, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Robot Knot-Tier tested in heart surgery
Knowledge-focused CompletedThis study collected information from multiple hospitals on the Cor-Knot® device, which automatically ties knots during heart valve surgery. The goal was to see how safe and effective it is. Over 550 adults having planned valve surgery took part. The main focus was on whether lea…
Sponsor: Centre Hospitalier Universitaire Dijon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Heart MRI study reveals hidden valve variation in thousands
Knowledge-focused CompletedThis study looked at 4,000 adults who had a heart MRI to find out how often a small heart valve variation called mitral annular disjunction (MAD) occurs. Researchers wanted to see if MAD is linked to heart valve problems or dangerous heart rhythms. The goal was to better understa…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC