Melancholia
MONDO:0002444A subtype of depression characterized by the inability to find pleasure in positive things combined with physical agitation, insomnia, or decreased appetite.
Also known as: depression with melancholic features, melancholic depression
49 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Can a video chat therapy reduce suicide risk? new study hopes to find out
Symptom relief OngoingThis pilot study tests whether a brief cognitive behavioral therapy delivered via video conference can help adults with mood disorders who are at high risk for suicide. Forty participants will either receive the video therapy plus usual care, or usual care alone. The study will m…
Phase: NA • Sponsor: Hyung Keun Park • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Virtual reality headsets tested to soothe ECT jitters
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…
Phase: NA • Sponsor: Universitair Ziekenhuis Brussel • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Can a brief online therapy ease anxiety and depression in kids? new study aims to find out.
Symptom relief ENROLLING_BY_INVITATIONThis study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…
Phase: NA • Sponsor: San Diego State University • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Gut health for the mind: postbiotics tested as mood boosters
Symptom relief OngoingThis study tests whether taking postbiotics (a dietary supplement) for 8 weeks can reduce depressive symptoms and improve mood in Korean adults aged 19-39 with mild to moderate mood issues. Fifty-two participants will receive either postbiotics or a placebo, and their mood will b…
Phase: NA • Sponsor: Hanyang University • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Withdrawn study aimed to boost mental health in young south asian women
Knowledge-focused TerminatedThis study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Scientists probe the Mind-Sleep connection with brain and heart scans
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how mood disorders and insomnia interact by monitoring heart and brain activity. Researchers will measure signals like heart rate variability and brain waves in 200 people, including healthy volunteers and those with mood or sleep issues. The goal is to unders…
Sponsor: Qilu Hospital of Shandong University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC