Low grade glioma

This phase III trial compares two chemotherapy approaches for children and young adults with previously untreated low grade glioma, a type of brain or spinal cord tumor. One group receives the standard combination of carboplatin and vincristine, while the other receives carboplat…

This pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…

This study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors. The goal was to see if the drug could shrink or slow the growth of these…

This study tested a drug called AB-218 (safusidenib) in 14 adults with a specific type of slow-growing brain tumor (IDH1 mutated low grade glioma) who were already scheduled for surgery. The goal was to see if it's possible to measure how much drug gets into the tumor and to chec…

This early-phase study tested two experimental drugs, AG-120 and AG-881, in 49 adults with a recurrent, slow-growing brain tumor (low grade glioma) that has a specific IDH1 gene mutation. The goal was to see if these drugs could lower a substance called 2-HG in the tumor tissue b…

This early-phase study tested a drug called Tovorafenib in 44 children with low-grade gliomas (a type of brain tumor) that had come back or continued growing despite other treatments. The main goal was to find the safest dose and check for side effects. The drug works by blocking…

This study tested a drug called MEK162 in 105 children with low-grade gliomas or other tumors that have a specific overactive growth signal. The goal was to find the best dose, check for side effects, and see if the drug could shrink tumors. Children took the drug by mouth twice …

This study tested whether a special dye called fluoroethyltyrosine (FET) can improve PET scans for detecting brain tumors that have come back. 143 people with suspected recurrent brain tumors received an injection of FET before their PET scan. The goal was to see if FET-PET could…

This early study tested a special light probe that helps surgeons see brain tumor tissue during an operation. Eleven adults with suspected brain tumors took part. The probe uses a drug that makes tumor cells glow, and the goal was to see if the device could accurately tell tumor …

This study looked at memory complaints in 426 people, including those with brain tumors, breast cancer, and healthy volunteers. Participants filled out questionnaires about their memory, mood, and fatigue. The goal was to understand how cancer and its treatments might affect ever…

This study tested a new type of MRI-like scan called Field Cycling Imaging (FCI) on 9 people who had surgery for low-grade gliomas. The goal was to see if FCI can tell apart different subtypes of these slow-growing brain tumors without needing another surgery or biopsy. Each part…

This study followed 26 adults with low-grade glioma who were receiving chemotherapy (temozolomide) for the first time after surgery. Researchers measured how the treatment affected patients' quality of life, thinking skills, and emotional well-being over one year. The goal was to…

This pilot study tested whether a special PET scan using 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part at Mayo Clinic. The goal was to see if the scan provides useful information b…