New hope for kids with tough brain tumors: experimental drug shows promise in early trial

NCT ID NCT03429803

Completed Disease control Sponsor: Karen D. Wright, MD Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase study tested a drug called Tovorafenib in 44 children with low-grade gliomas (a type of brain tumor) that had come back or continued growing despite other treatments. The main goal was to find the safest dose and check for side effects. The drug works by blocking a specific pathway that helps these tumors grow.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

low grade glioma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW GRADE GLIOMA

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Hospital Los Angeles

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Minnesota

Minneapolis, Minnesota, 55404, United States
Children's National Hospital

Washington D.C., District of Columbia, 20010, United States
Dana-Farber Cancer Institite

Boston, Massachusetts, 02215, United States
Johns Hopkins University

Baltimore, Maryland, 21287, United States
Massacusetts General Hospital

Boston, Massachusetts, 02114, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Seattle Children's Hospital

Seattle, Washington, 98105, United States
University of California, San Diego

San Diego, California, 92123, United States
University of California, San Francisco

San Francisco, California, 94158, United States
University of Florida

Gainesville, Florida, 32610, United States
University of Utah

Salt Lake City, Utah, 84113, United States
Washington University in St. Louis

St Louis, Missouri, 63110, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.