Leukoplakia
MONDO:0043243A white patch or plaque on a mucous membrane that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc., must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition.
Also known as: keratotic plaque, leukoplakia, lesion, leukoplakic, lesions, leukoplakic, leukokeratoses, leukokeratosis, leukoplakias, leukoplakic lesion
34 clinical trials for this condition and its sub-types.
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Broader categories
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Genetically modified cells injected into mouth lesions to stop cancer before it starts
Disease control Not yet recruitingThis early-phase trial tests whether specially engineered immune cells (NK cells) can safely treat high-risk precancerous spots in the mouth. The cells are injected directly into the lesions and are designed to target a protein called TROP2, while also resisting signals that norm…
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New light treatment could fight oral cancer without surgery
Disease control Not yet recruitingThis study tests a low-cost approach to treat pre-cancerous and cancerous mouth lesions using a drug (5-ALA) that makes abnormal cells sensitive to light, followed by laser light delivered through a handheld device. The goal is to destroy these lesions without surgery. The trial …
Phase: PHASE2 • Sponsor: University of Massachusetts, Boston • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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Light therapy vs. vitamin d cream: new hope for oral cancer prevention?
Disease control Not yet recruitingThis study tests two non-surgical treatments for oral leukoplakia, a white patch in the mouth that can turn into cancer. One treatment uses a light-activated dye (photodynamic therapy) and the other uses a vitamin D-based cream (calcipotriol). The goal is to see which works bette…
Phase: PHASE3 • Sponsor: Dr. Shalini Gupta • Aim: Disease control
Last updated Jun 27, 2026 09:10 UTC
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AI-Powered endoscopy aims to spot head and neck cancer earlier
Diagnosis Not yet recruitingThis study will test artificial intelligence algorithms that analyze video from routine endoscopies of the head and neck. The AI will try to detect, classify (benign vs. malignant), and outline lesions, comparing its performance to doctors and lab results. About 283 adults with s…
Sponsor: Istituto Italiano di Tecnologia • Aim: Diagnosis
Last updated Jun 27, 2026 12:35 UTC
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AI could help dentists detect oral cancer earlier without a biopsy
Diagnosis Not yet recruitingThis study will test whether artificial intelligence can help diagnose oral lesions that might turn into cancer. Researchers will use photos of the lesions and cell samples from the mouth, along with a special blue stain, to train an AI model. The goal is to see if the AI can mat…
Sponsor: Ain Shams University • Aim: Diagnosis
Last updated Jun 27, 2026 08:09 UTC