Klebsiella infectious disease

This trial tests whether a 7-day course of doxycycline can effectively cure asymptomatic anal lymphogranuloma venereum (LGV), a sexually transmitted infection caused by Chlamydia trachomatis. Currently, treatment lasts 21 days, but recent studies suggest a shorter course may work…

This early-stage study tests whether adding specially-made viruses (phages) to standard antibiotics can safely treat stubborn lung infections in adults with cystic fibrosis. About 30 participants will receive a 7-day course of both treatments. The main goal is to check safety, bu…

This study looks at whether the standard dose of the antibiotic ceftazidime-avibactam reaches high enough levels in the blood of people with blood cancers or those who have had a stem cell transplant. These patients are at high risk for severe infections from drug-resistant bacte…

This study investigates whether a particularly dangerous strain of Klebsiella pneumoniae bacteria (hvKP) raises the risk of lung injury in adults with sepsis, compared to a more common strain. Researchers will analyze blood samples for tiny bacterial particles and markers of a sp…

This study aims to find out how often multi-drug resistant Klebsiella pneumoniae bacteria carry genes that help them form biofilms (sticky layers) and pump out antibiotics. Researchers will collect urine, pus, and sputum samples from 100 hospital patients with these infections. T…

This study looks at whether certain genes in a dangerous superbug (carbapenem-resistant hypervirulent Klebsiella pneumoniae) make it resistant to the powerful antibiotic cefiderocol. Researchers will collect samples from 100 infected patients and test the bacteria in the lab. The…

This study will test the antibiotic combination ceftazidime-avibactam on 100 patients with healthcare-associated infections caused by carbapenem-resistant Klebsiella pneumoniae. Researchers will collect samples from blood, urine, and other sites to identify the bacteria and check…