Hypogonadism
MONDO:0002146A disorder characterized by decreased function of the gonads. Clinical manifestations in both males and females include poor libido, infertility, and osteoporosis. Additional signs in males include erectile dysfunction, muscle atrophy, gynecomastia and increased abdominal fat. In females, additional signs include shrinking of the breasts and loss of, or failure to develop menstruation.
Also known as: gonadotropin deficiency, hypogonadotropism
164 clinical trials for this condition and its sub-types, 47 tagged with Hypogonadism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Part of
Sub-types of Hypogonadism
-
Hypogonadotropic hypogonadism 19 trials · 100 incl. sub-types
10 sub-types
- Congenital hypogonadotropic hypogonadism 0 trials · 83 incl. sub-types Sub-types →
- Kallmann syndrome 3 trials Sub-types →
- Hypogonadotropic hypogonadism 24 without anosmia 1 trial
- Hypogonadotropic hypogonadism 10 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 12 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 13 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 23 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 25 with anosmia 0 trials
- Hypogonadotropic hypogonadism 26 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 27 without anosmia 0 trials
-
Gonadal dysgenesis 1 trial · 32 incl. sub-types
5 sub-types
- Turner syndrome 29 trials Sub-types →
- 46 XX gonadal dysgenesis 1 trial Sub-types →
- 46,XY complete gonadal dysgenesis 0 trials · 1 incl. sub-types Sub-types →
- 45,X/46,XY mixed gonadal dysgenesis 0 trials
- Testicular dysgenesis syndrome 0 trials
-
Hypogonadism, male 24 trials
-
Eunuchism 16 trials
-
Slti-Salem syndrome 0 trials
-
Weinstein kliman scully syndrome 0 trials
Most studied deeper sub-types
-
AI-Crafted supplement aims to restore testosterone naturally
Disease control By invitation onlyThis trial tests whether a daily nutritional supplement, designed with artificial intelligence to target gut bacteria, can increase testosterone production in men aged 30-65 with functional secondary hypogonadism—a condition where the body doesn't make enough testosterone despite…
Sponsor: Varol TUNALI • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
-
Could a testosterone shot before surgery speed recovery?
Disease control OngoingThis early-phase trial is testing whether giving testosterone replacement therapy to men with low testosterone before and after major urologic surgery is safe and might improve recovery. Researchers will track quality of life, frailty, complications, hospital stay length, and rea…
Phase 1 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
-
Testosterone drug JATENZO under safety spotlight for adrenal impact
Disease control OngoingThis Phase 4 study is checking whether JATENZO, a testosterone replacement drug, affects adrenal gland function in men with low testosterone (hypogonadism). About 110 men aged 18-65 will take JATENZO for 12 months. Researchers will measure cortisol levels after a stimulation test…
Phase 4 • Sponsor: Tolmar Inc. • Aim: Disease control
Last updated Jun 26, 2026 14:07 UTC
-
Testosterone gel trial aims to beat cancer fatigue in older men
Symptom relief OngoingThis study is testing whether a daily testosterone gel can reduce fatigue and improve sexual function in men aged 55 and older who have cancer and low testosterone. The trial involves 230 participants who will apply either the gel or a placebo for six months. Researchers will mea…
Phase 2 • Sponsor: Seattle Institute for Biomedical and Clinical Research • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
-
Super MRI scans peek inside brains of testicular cancer survivors
Knowledge-focused PausedThis study uses a very powerful 7 Tesla MRI scanner to take detailed pictures of the brain in testicular cancer patients who have low testosterone (hypogonadism) and are on testosterone replacement therapy. The goal is to see if the MRI can detect changes in brain structure and f…
Sponsor: University of Southern California • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC