Testosterone drug JATENZO under safety spotlight for adrenal impact

NCT ID NCT06385509

Ongoing Disease control Sponsor: Tolmar Inc. Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This Phase 4 study is checking whether JATENZO, a testosterone replacement drug, affects adrenal gland function in men with low testosterone (hypogonadism). About 110 men aged 18-65 will take JATENZO for 12 months. Researchers will measure cortisol levels after a stimulation test to see if adrenal problems develop.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

JATENZO (testosterone undecanoate)

What this could lead to

If successful, this study could confirm that JATENZO is safe for adrenal function in men with low testosterone, supporting its continued use.

What could go wrong

This is a small, open-label Phase 4 safety study, not designed to prove effectiveness. Results may not apply to all patients, and adrenal issues could still occur.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

hypogonadism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPOGONADISM

Contacts and locations

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Locations

AccuMed Research Associates

Garden City, New York, 11530, United States
Alliance for Multispecialty Research

Tempe, Arizona, 85281, United States
Alliance for Multispecialty Research

Norfolk, Virginia, 23507, United States
Alpine Research Organization, Inc.

Clinton, Utah, 84015, United States
Catawba Valley Medical Group, Inc.

Hickory, North Carolina, 28602, United States
Centennial Medical Group

Columbia, Maryland, 21045, United States
Clinical Investigation Specialists, Inc.

Kenosha, Wisconsin, 53144, United States
Clinical Research Center of Florida

Pompano Beach, Florida, 33060, United States
Clinical Trials Research

Lincoln, California, 95648, United States
Epic Medical Research LLC

DeSoto, Texas, 75115, United States
Global Health Clinical Trial Crop

Miami, Florida, 33135, United States
Highland Clinical Research

Salt Lake City, Utah, 84124, United States
Hillcrest Medical Research, LLC

DeLand, Florida, 32720, United States
Integrated Clinical Research

Tarzana, California, 91356, United States
Long Beach Research Institute, LLC

Long Beach, California, 90805, United States
Piedmont Healthcare, PA

Statesville, North Carolina, 28625, United States
Raleigh Medical Group

Raleigh, North Carolina, 27609, United States
Renstar Medical Research

Ocala, Florida, 34470, United States
Reserka LLC

Miami, Florida, 33176, United States
Rochester Clinical Research, LLC

Rochester, New York, 14609, United States
SMS Clinical Research LLC

Mesquite, Texas, 75149, United States
VAST Clinical Research LLC

Garland, Texas, 75041, United States
Velocity Clinical Research

Savannah, Georgia, 31406, United States
Velocity Clinical Research

Omaha, Nebraska, 68134, United States
Velocity Clinical Research

Austin, Texas, 78759, United States
Velocity Clinical Research, Inc.

Durham, North Carolina, 27701, United States
Wilmington Health, PLLC

Wilmington, North Carolina, 28401, United States