Hyperthyroidism

This study tests whether BHV-1300 can help adults with Graves' disease achieve normal thyroid function without antithyroid drugs. Participants receive either BHV-1300 or a placebo via injection. The main goal is to see if more people on BHV-1300 have normal thyroid hormone levels…

This phase 2 trial tests whether felzartamab, an antibody that targets immune cells producing harmful antibodies, can restore normal thyroid function in people with Graves' disease. Participants will receive either felzartamab or a placebo alongside their usual anti-thyroid drugs…

This phase 2 trial tests an experimental drug called YB-101 in people with Graves' disease, an autoimmune condition that causes an overactive thyroid. The study will see if YB-101 can help normalize thyroid hormone levels and allow patients to stop taking anti-thyroid medications…

This phase 2b trial tests an experimental drug called IMVT-1402 in 240 adults with Graves' disease whose thyroid is still overactive despite standard treatment. The goal is to see if the drug can help patients achieve normal thyroid hormone levels and stop taking antithyroid medi…

This early-stage trial tests a new biologic drug called MER511 in 100 adults with Graves' disease. The main goal is to check safety and side effects, and to see how the body handles the drug when given by IV or injection. Participants must be on stable thyroid medication. The stu…

This early study is testing a new drug called BHV-1300 in 15 people with Graves' disease. The main goal is to see if the drug is safe and to check how it affects certain markers of the disease. This is a phase 1 trial, so it's one of the first steps in testing this treatment in h…

This study tests a new approach for treating hyperthyroidism (overactive thyroid) by combining a minimally invasive heat procedure with standard medication. About 454 adults with hyperthyroidism will receive thermal ablation to destroy overactive thyroid tissue, plus antithyroid …

This study looks at whether giving Lugol's solution before removing the thyroid gland can lower the chance of two common surgery complications: low calcium levels from damaged parathyroid glands and vocal cord weakness from nerve injury. About 182 adults with overactive thyroid f…

This pilot study tests whether adding high-dose vitamin D to standard methimazole therapy helps control thyroid function and antibodies in children aged 9-17 newly diagnosed with Graves' disease. The main goal is to see if a larger trial is possible by measuring recruitment, adhe…

This study tests a software called Glandy HYPER that uses artificial intelligence to detect thyrotoxicosis—a dangerous overactive thyroid state—in people with Graves' disease. The AI analyzes resting heart rate data from wearable devices like smartwatches and compares it with sta…

This study follows up to 2,500 people with thyroid problems like hyperthyroidism, hypothyroidism, or Graves' disease. Researchers will track how these conditions develop over time using standard medical tests and genetic samples. The goal is to better understand the natural histo…

This study tests whether a smart wristband that records nighttime heart rate and rhythm can tell if the dose of thyroid medication (levothyroxine) is too high or too low after total thyroid removal. Forty adults will wear the wristband for the first month after surgery, and the d…

This study tests whether a nerve block in the neck, given during thyroid surgery, can lower the body's stress response. 48 adults will be split into two groups: one gets standard anesthesia, the other gets the same plus a nerve block. Researchers will measure stress markers in bl…

This study looks at how changing thyroid hormone levels affect the way the body uses sugar and fat. Researchers will study people with Graves' disease (whose thyroid hormones are too high) and people with thyroid cancer (whose hormones are intentionally raised). Participants will…

This study is checking if thyroid problems (too much or too little thyroid hormone) change results of liver function tests. Researchers will measure bilirubin levels in 100 adults aged 20-60, comparing those with thyroid disease to healthy volunteers. The goal is to better unders…